The kinase CK1α coordinates the initiation and termination of the cGAS-STING pathway.

Jane Jardine Marine Tarrillon G. André-Grégoire K. Trillet Vanessa Josso Laura Merlet Rosalie Moreau Célia Jaunasse Luc Antigny S. Marionneau‐Lambot F. Guillonneau A. Boissard Cécile Henry Joanna Re S. Barillé-Nion N. Laguette Philippe P. Juin J. Gavard N. Bidère

Aug 2026 · Cell Death and Differentiation · 0 citations · 78 references

Medicine

TL;DR

It is reported that Casein Kinase 1 alpha operates as a bimodal regulator of the cGAS-STING pathway, and selective degradation of CK1α using molecular-glue degraders suppressed aberrant cGAS-STING-driven inflammation signaling in a chromosomally unstable triple-negative breast cancer cell line.

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