It is implied that resveratrol improves the antioxidant status of the body against diazinon toxicity, so it can improve renal function in the face of diazinon.
Dichlorvos is an organophosphate insecticide widely used in domestic and agricultural settings, and exposure is associated with significant toxicological effects, largely mediated by oxidative stress. This study evaluated the protective effects of the flavonoids quercetin and naringin against dichlorvos-induced subacute toxicity in male Wistar rats. Eighty male albino rats were randomly allocated into eight groups (n = 10); negative control (water), positive (vehicle) control (Dimethyl sulfoxide (DMSO)), Dichlorvos (8mg/kg BW), Dichlorvos recovery, Dichlorvos + naringin, Dichlorvos + quercetin, quercetin only, naringin only, and orally treated for 28 days. At the end of the experimental period, plasma, red blood cells, liver, and brain samples were collected for biochemical analyses. Activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST) were determined spectrophotometrically. Subacute dichlorvos (28-day) exposure caused significant reductions in SOD, CAT, and GST activities across all examined tissues, reflecting impaired antioxidant defense and increased oxidative stress. Coadministration of quercetin or naringin significantly attenuated these alterations, with enzyme activities approaching control levels. Quercetin showed greater protective efficacy in liver and brain tissues, whereas naringin exerted comparatively stronger effects in plasma and red blood cells, indicating tissue-specific antioxidant responses. Overall, the findings demonstrate that quercetin and naringin effectively protect against dichlorvos-induced subacute toxicity by modulating endogenous antioxidant enzymes, supporting the potential use of dietary flavonoids as adjunct protective agents against organophosphate toxicity.
A. Wusu, L. D. Adeleke, R. Kanmodi et al.· The Scientific World Journal· 0 citations
It is demonstrated that MAL induces hepatotoxicity by promoting oxidative stress, inflammation, and apoptosis, whereas morin exerts significant hepatoprotective effects, likely through modulation of antioxidant defense systems and apoptotic pathways.
Seval Yılmaz, Eda I. Demirbağ, Hakan Bağ et al.· Environmental Toxicology· 0 citations
Di-n-butyl phthalate (DBP), a widely used plasticizer, induces oxidative stress and neurotoxicity through the generation of reactive oxygen species. Ellagic acid (EA), a natural polyphenolic antioxidant, may counteract these effects. This study aimed to evaluate the protective role of EA against DBP-induced oxidative brain injury. Thirty-two male rats were randomly divided into four groups: Control, DBP, EA, and DBP+EA. DBP was administered orally at a dose of 500 mg/kg/day, while EA was given by gavage at 2 mg/kg/day for four weeks. Oxidative stress parameters, including thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activities were analyzed in brain tissue. DBP exposure significantly increased TBARS levels while decreasing GSH and SOD activities, indicating lipid peroxidation and antioxidant depletion. In contrast, CAT activity was elevated, suggesting a compensatory enzymatic response to excess hydrogen peroxide. EA treatment markedly attenuated oxidative damage by restoring GSH and SOD levels and normalizing CAT activity. These findings indicate that DBP disrupts redox homeostasis by inducing lipid peroxidation, while EA mitigates this effect through restoration of antioxidant defenses.
İdris Ayhan, Neşe Başak Türkmen, Demet Döndü Kasım et al.· Muğla Sıtkı Koçman Üniversit...· 0 citations
Potassium bromate (KBrO₃) is a potent oxidizing agent that induces oxidative stress and hepatic injury. This study investigated the protective effects of flavonoids extracted from Solanum aethiopicum leaves against KBrO₃-induced alterations in liver function, antioxidant status, and lipid profile in Wistar rats. Thirty rats were randomly assigned to six groups (n = 5): normal control, S. aethiopicum flavonoids (500 mg/kg), KBrO₃ (50 mg/kg), KBrO₃ + flavonoids (250 mg/kg), and KBrO₃ + flavonoids (500 mg/kg). At the end of the treatment period, serum liver function indices, antioxidant enzymes were determined using standard biochemical methods. Potassium bromate significantly (P < 0.05) reduced serum total protein, albumin, globulin, glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT), while significantly increasing alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin, malondialdehyde (MDA). Administration of S. aethiopicum flavonoids significantly reversed these alterations in a dose-dependent manner, with the 500 mg/kg dose showing greater protective effects than the 250 mg/kg dose. The flavonoid extract restored antioxidant enzyme activities, improved liver synthetic and excretory functions. These findings demonstrate that flavonoids extracted from Solanum aethiopicum leaves possess significant hepatoprotective, antioxidant properties against potassium bromate-induced toxicity. The observed protective effects are likely mediated through free radical scavenging, preservation of hepatocyte membrane integrity, and enhancement of endogenous antioxidant defenses. Solanum aethiopicum flavonoids therefore represent a promising natural therapeutic candidate for the prevention and management of oxidative stress-mediated liver dysfunction and associated metabolic disturbances.
Keywords: Hepatoprotective, antioxidants, flavonoids, Solanum aethiopicum, potassium bromate.
Okon Victoria Edem, Agabi Martina· IDOSR JOURNAL OF BIOCHEMISTR...· 0 citations
Background: Aniline is an industrial chemical whose reactive metabolites induce oxidative stress and structural damage in splenic tissue, making aniline-induced splenic toxicity in rats a well-established experimental model for evaluating protective interventions. Rosmarinus officinalis L. (rosemary) possesses potent antioxidant and anti-inflammatory phytochemicals that may mitigate chemically induced tissue injury. Aim: To investigate the antioxidant-mediated splenoprotective effects of Ethanolic Rosemary Extract (ERE) against aniline-induced splenic toxicity in male Wistar rats. Methods: Male Wistar rats (200-250 g) were randomly divided into five groups (n = 6) and treated for 30 days. Splenic toxicity was induced by oral administration of aniline hydrochloride (50 mg/kg/day). Protective treatment groups received ERE at doses of 100 or 200 mg/kg/day orally, while citric acid (100 mg/kg/day, p.o.) served as the reference standard. Physiological parameters, oxidative stress biomarkers, antioxidant enzyme activities (GSH and CAT), ATPase activity, serum biochemical indices, histopathological changes, and hemosiderin deposition were assessed. Statistical analysis was performed using one-way ANOVA, with p<0.05 considered statistically significant. Results: Aniline administration produced splenomegaly, excessive iron accumulation, elevated lipid peroxidation, impaired antioxidant defences, reduced ATPase activity, and pronounced histopathological alterations including fibrosis and disruption of normal splenic architecture. Treatment with ERE significantly ameliorated these toxic effects in a dose-dependent manner. Rosemary extract restored antioxidant enzyme levels, reduced lipid peroxidation and nitric oxide production, improved ATPase activity, decreased hemosiderin deposition, normalised haematological and biochemical parameters, and preserved splenic histoarchitecture. The higher dose (200 mg/kg) demonstrated the greatest protective efficacy. Conclusion: ERE effectively protects against aniline-induced splenic toxicity by attenuating oxidative stress, restoring antioxidant defences, reducing iron accumulation, and preserving tissue architecture, suggesting its potential as a natural splenoprotective agent.
Major Findings: ERE significantly ameliorated oxidative stress, restored antioxidant enzyme activity, improved haematological indices, reduced splenic iron overload, and preserved splenic histoarchitecture, with the 200 mg/kg dose producing the greatest protective effect.
C. Patil, Durgesh Pagar, Kajal Pansare et al.· Journal of Natural Remedies· 0 citations
Rutin serves as an effective protective agent against NPL-associated infertility and reproductive failure by modulating steroidogenic, inflammatory, and apoptotic pathways and establishes a foundation for using natural polyphenols to counteract the reproductive risks posed by environmental contaminants.
Doaa A Madkour, Mohamed M. Ahmed, A. Elkirdasy et al.· Alexandria Journal of Veteri...· 0 citations
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