Abstract Background LSD has recently entered phase 3 clinical trials for anxiety and depressive disorders, yet understanding of its mechanisms of action in the human brain remains incomplete. The serotonin 2A receptor (5-HT2AR) is the critical target for psychedelic effects, but no investigations to date have evaluated...
D. McCulloch· International Journal of Neu...· 0 citations
Highlights What are the main findings? A dose of purified cannabidiol did not significantly alter cortical excitability or established GABAergic biomarkers. The drug exhibited a trend toward increased alpha and decreased delta neural synchronization compared to placebo. What are the implications of the main findings? T...
V. Santoro, Po-Yu Fong, A. Biondi et al.· Brain Science· 0 citations
Psychedelics are increasingly explored as tools to investigate consciousness and cognition, and as potential treatments for mood disorders. While neuroimaging has been central to characterizing their mechanisms of action, the interpretation of these studies may be confounded by the neurovascular effects elicited by the...
Lautaro Mundel, V. Medel, C. Timmermann et al.· bioRxiv· 0 citations
Abstract Background Clinical studies have shown that ketamine and classic psychedelics can produce robust and rapid antidepressant effects after a single or a few administrations. However, the neurobiological mechanisms driving these long-lasting changes remain unclear. A leading framework proposes that both drug class...
C. Agnorelli, J. Peill, D. Kurtin et al.· International Journal of Neu...· 0 citations
Findings suggest that while acute LSD, at high doses decreases decreased theta, beta, and gamma power and 5-HT firing activity, after repeated LSD may counteract stress-induced anxiety by enhancing cortical synaptic plasticity and serotonergic neurotransmission, potentially via 5-HT₁A receptor desensitization at the pr...
G. Gobbi· International Journal of Neu...· 0 citations
Background Classical psychedelics induce profound changes in brain function, yet the temporal organization of these effects remains incompletely understood. Methods We investigated the effects of acute lysergic acid diethylamide (LSD) on large-scale brain connectivity in nine male Long–Evans rats using resting-state fu...
F. Hilal, Rayane Benkeddada, J. Jeanblanc et al.· bioRxiv· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.