Sep 2026· Italian National Conference on Sensors· Vol 26· 0 citations· 39 references
Medicine
Abstract
In this work, a compact dual-parameter fiber optic sensor for temperature, refractive index, and label-free biomarker-related measurements is presented. The sensor is based on a chirped fiber Bragg grating cleaved inside the grating region, leaving residual grating lengths of 3 mm, 4 mm, and 5 mm. After cleaving, the reflected spectrum becomes narrower and forms clear sidelobes, allowing the main-band wavelength shift to be used for temperature monitoring, while the sidelobe intensity variation is used for refractive index detection. Temperature calibration from 25 °C to 80 °C showed approximately linear responses with sensitivities close to 10 pm/°C. Refractive index calibration in 10–15% sucrose solutions showed a monotonic decrease in sidelobe intensity with increasing refractive index, with sensitivities reaching about −220 dB/RIU for selected valley features and around −200 dB/RIU in the matrix analysis. An extended calibration from 0% to 35% sucrose confirmed that the RI-dependent response was maintained over a broader range, although with increased nonlinearity. Cross-sensitivity coefficients were incorporated into 2 by 2 sensitivity matrices and their inverses for simultaneous parameter reconstruction. Additional measurements under combined temperature and sucrose concentration changes demonstrated temperature reconstruction with RMSE values of 0.87–2.69 °C, depending on the sensor and experimental conditions. Finally, as a proof-of-concept experiment, the cleaved-CFBG sensors were biofunctionalized with anti-VEGF antibodies and tested for VEGF detection from 10−15 M to 10−10 M. Overall, the proposed design is simple, compact, compatible with standard interrogation systems, and shows promise as a thermo-refractometric platform for biomedical biosensing applications.
In-line fiber Mach–Zehnder interferometers (MZIs) have been widely investigated for refractive index (RI) sensing; however, variations in temperature affect the accuracy of RI measurement due to the thermo-optic effect. In this study, a cascaded core-offset in-line fiber MZI was simulated and experimentally demonstrate...
We report a liquid-level sensor based on the air-cladding-mode band of a 37.5° tilted fiber Bragg grating (TFBG). Partial immersion increases the radiative loss of this mode band, and the liquid level is retrieved from the integrated area between its fitted upper and lower spectral envelopes. The sensor exhibits a sens...
Jia-Hao Dong, Zhen-Cheng Li, Kai-Wei Li et al.· Optics Letters· 0 citations
A femtosecond optical-frequency-comb-based dispersive interferometric method is proposed for high-precision bulk-liquid group refractive index measurement. Broadband spectral interferograms are transformed into the delay domain, where the target side peak is selected by window filtering. The single-pass-equivalent opti...
Xin Xu, Xin-Yu Liu, Xiu Li et al.· Measurement science and tech...· 0 citations
High-precision refractive index measurement of liquid is widely demanded in chemical analysis, biochemical detection and environmental monitoring. A hybrid fiber-optic Mach-Zehnder interferometer (MZI) refractive index measurement system combining fiber transmission and free-space interference is proposed in this paper...
Yao-Rui Liu, Jia-Hao Zhong, Zi-Guo Yang et al.· Conference on Optics and Com...· 0 citations
Plasmonic refractive-index sensors provide a powerful route for label-free detection, but their performance is often limited by the trade-off between sensitivity and resonance linewidth. Here, we propose a magneto-optical hyperbolic metamaterial platform for high-resolution refractive-index sensing at the telecom wavel...
B. F. Diaz-Valencia, J. Mej'ia-Salazar· Nanoscale Advances· 0 citations
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