The results suggest that the anterior cingulate can be a core cortical structure for the bilateral propagation of CM stimulation, and DTI findings indicate that the propagation of CM stimulation may rely upon integrity of structural connections between CM and these key cortical regions.
Overall, the available evidence supports a transition from a predominantly hippocampocentric framework toward a distributed thalamocortical network model of TLE, and emerging longitudinal evidence further suggests that thalamocortical networks may undergo postoperative reorganization following successful epilepsy surge...
G. Bevacqua, Marco Ciavarro, L. Gaetani et al.· Brain Structure and Function· 0 citations
Objective. Temporal lobe epilepsy (TLE) is associated with disrupted functional integrity in the amygdala-hippocampus complex. Cortico-cortical evoked potentials (CCEPs) can characterize this disruption and have been proposed as biomarkers of the epileptogenic zone (EZ), but their study is typically limited by the spat...
O. Feys, M. Josyula, Nilu Sinha et al.· medRxiv· 0 citations
OBJECTIVE
Although the centromedian nucleus of the thalamus (CM) is an increasingly considered deep brain stimulation (DBS) target for drug-resistant epilepsy (DRE), there is significant variability in programming practices, which may contribute to heterogenous outcomes. We systematically described stimulation paramete...
M. AlQahtani, Michal Stern-Zimmer, P. Jain et al.· Epilepsia· 0 citations
Objective Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) is an established palliative therapy for drug-resistant focal epilepsy; however, its efficacy for epileptic spasms (ES) and the clinical utility of unilateral stimulation remain unclear. To address these issues, we report a case of drug-...
Takumi Mitsuhashi, Y. Iimura, Hiroharu Suzuki et al.· Epilepsy & Behavior Reports· 0 citations
Patients with disorders of consciousness (DoC) lack effective non-invasive neuromodulation therapies capable of targeting deep-brain arousal circuits. Temporal interference stimulation (TIS) offers potential for non-invasive deep brain targeting. However, its efficacy, optimal stimulation parameters, and underlyi...
Ze Wu, Long Zeng, An-Bo Zhang et al.· Journal of Translational Med...· 0 citations
The multimodal findings suggest that increased hippocampal connectivity in the epileptogenic hemisphere may reflect pathological hypersynchronization that disrupts efficient memory network coordination in TLE and highlight hippocampal connectivity as a promising candidate biomarker for characterizing individual memory...
Ruxue Gong, Xiaolong Peng, Rebecca W. Roth et al.· Epilepsia· 0 citations
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