Emerging Medicinal Plants and Their Therapeutic Potential in Hyperuricemia and Gout Management: A Review
TL;DR
This review explores the pathophysiology behind hyperuricemia-gout association of various plants like Dendrobium officinale, Mollugo pentaphylla, Sophora japonica, Aster glehni, Eucommia ulmoides, Mesona procumbens, among others and concludes that more research is needed for their clinical utility.
Abstract
Hyperuricemia is a condition characterized by elevated concentrations of uric acid in the body which is a metabolic disorder that leads to gout. It is also linked to other complications such as renal disorders, heart diseases, and metabolic syndrome. Even though treatments such as allopurinol, febuxostat, colchicine, and non-steroidal anti-inflammatory medicines have proved to be quite effective in the management of hyperuricemia but causes side effects, thus responsible for health risks on prolonged usage. Thus, there is need to much focus on herbal treatments of hyperuricemia and gout.This review explores the pathophysiology behind hyperuricemia-gout association of various plants like Dendrobium officinale, Mollugo pentaphylla, Sophora japonica, Aster glehni, Eucommia ulmoides, Mesona procumbens, among others. These plants have been reviewed extensively in the literature for their potential medicinal value. These were based on the various pharmacological activities they possess through mechanisms of xanthine oxidase inhibition, renal urate transporter modulation, anti-inflammatory activity, and antioxidant-mediated protection against nephropathy. While promising preclinical data exist, more research is needed for their clinical utility.