Jul 2026· Jana Nexus: Journal of Health and Medicine· 0 citations
TL;DR
Recent advances in molecular diagnostics, including bone turnover biomarkers, genomics, epigenomics, transcriptomics, proteomics, metabolomics, and liquid biopsy approaches, are transforming the laboratory follow-up of postmenopausal osteoporosis.
Abstract
Postmenopausal osteoporosis (PMO) is a systemic skeletal disorder characterized by reduced bone mass and microarchitectural deterioration of bone tissue, leading to increased fragility and fracture risk. The decline in estrogen levels after menopause accelerates bone remodelin, favoring osteoclastic bone resorption over osteoblastic bone formation. Osteoporotic fractures remain a major cause of morbidity, mortality, and healthcare expenditure worldwide. While dual- energy X- ray absor Ptiometry (DXA) remains the gold standard for diagnosis and monitoring, growing evidence suggests that molecular laboratory techniques can provide earlier and more sensitive insights into bone metabolism, treatment response, and fracture risk. Recent advances in molecular diagnostics, including bone turnover biomarkers, genomics, epigenomics, transcriptomics, proteomics, metabolomics, and liquid biopsy approaches, are transforming the laboratory follow-up of postmenopausal osteoporosis.
A practical clinical framework is proposed that integrates endocrine phenotype, vertebral imaging, trabecular bone score, and biochemical assessment into fracture-risk stratification and therapeutic decision-making, enabling improved identification of high- and very-high-risk patients and facilitating the appropriate use of anabolic and antiresorptive therapies.
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Runna Bhattacharjee· International Journal For Mu...· 0 citations
Existing and novel Osteoporosis biomarkers, their mechanisms, clinical efficacy, drawbacks, and the best biomarkers in Osteoporosis risk stratification and management are discussed, to convert them into better patient care.
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Results indicate that radiofrequency echographic multispectrometry provides BMD and fracture risk assessment comparable to DXA in patients on peritoneal dialysis, while also highlighting the impact of vascular calcifications on the diagnostic accuracy of lumbar spine DXA measurements.
O. I. Nishkumay, O. B. Iaremenko, V. Kondratiuk et al.· International Journal of End...· 0 citations
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Sheng-Yao Peng, Z. Yao, Jun-Zhe Guo et al.· International Journal of Mol...· 0 citations
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