Comparison of a Modified Regimen of Prophylactic Phenylephrine Boluses Versus Variable Rate Infusion During Elective Cesarean Delivery Under Spinal Anesthesia: A Noninferiority Randomized Double-Blind Study.
The modified regimen of prophylactic boluses is non-inferior to variable rate prophylactic phenylephrine infusion in terms of physician interventions needed to maintain systolic blood pressure within the target range and maternal and neonatal outcomes.
Cesarean section spinal anesthesia is often associated with maternal hypotension, which causes poor maternal and infant outcomes. Phenylephrine is commonly used as prophylaxis and treatment of spinal-induced hypotension, but the most effective mode of administration, bolus or continuous infusion, is controversial. Obje...
Anum Afzal, Muhammad Abdul Aziz, Ali Asad et al.· Pakistan journal of health s...· 0 citations
Hypotension following neuraxial anesthesia is one of the most common complications during cesarean delivery. This study aimed to evaluate the effects of phenylephrine and norepinephrine on placental vascular resistance under neuraxial anesthesia for cesarean section using Doppler ultrasonography.
Seventy-s...
Introduction: Spinal anesthesia-induced hypotension (SAIH) remains one of the most frequent hemodynamic complications during spinal anesthesia, particularly among high-risk surgical patients. Vasopressor agents such as phenylephrine and ephedrine are commonly administered to prevent hypotension; however, their comparat...
Awaluddin Awaluddin, Mhd Ihsan, B. Lubis et al.· JURNAL ILMIAH KESEHATAN SAND...· 0 citations
Shivering after spinal anesthesia for cesarean delivery is common and may increase metabolic demand, impair monitoring, and reduce maternal comfort. Dexmedetomidine is effective for control of shivering, but the optimal intravenous treatment dose remains uncertain. This prospective randomized double-blind trial compare...
Vinay Kejdiwal, J. Dsouza, Shweta Sinha et al.· AANA journal· 0 citations
The findings indicate that obese parturients require a significantly higher prophylactic dose of norepinephrine infusion to prevent spinal anesthesia-induced hypotension compared to the non-obese counterparts and underscore the importance of individualized dosing strategies based on BMI to optimize hemodynamic manageme...
Rui Ran, Li-Meng Liu, Wen-Qian Li et al.· Frontiers in Pharmacology· 1 citation
Low-dose intravenous esketamine 0.15 mg/kg may be a practical bridging adjunct during emergency conversion from labor epidural analgesia to Category I cesarean section and improved early pain control and target sedation without a clear adverse signal in systolic blood pressure, heart rate, oxygenation, or early Apgar s...
W. Liang, L. Zhai· medRxiv· 0 citations
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