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Human brain cortical oxygen consumption is positively related to soma surface area density

M. Carriero Alessandra Caporale D. di Censo Ian D. Driver E. Fear H. Chandler F. Fasano D. Zacà Emma Biondetti C. McNabb M. Germuska Derek K. Jones Marco Palombo R. G. Wise AM Chiarelli

Sep 2026 · bioRxiv · 0 citations · 74 references

Biology

TL;DR

A simple quantitative framework is established linking cerebral oxygen metabolism to gray matter microstructural features in healthy humans using advanced non-invasive MRI methods, providing the first quantitative evidence that cerebral metabolic demand is coupled to microstructure in humans.

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