Exploring the Molecular Mechanisms of SB216763 in the Therapeutic Intervention of Pulmonary Fibrosis Based on Macrophage Functional Plasticity‌

Molecular insights of a Unani formulation in targeting fibrosis-associated diseases

This PUF is considered as a potential integrative therapeutic approach for fibrosis-related diseases and for aggressive cancers with fibrosis, and is expected to target both tumour cells and the fibrotic tumour micro-environment, thereby integrating ethnopharmacological knowledge with molecular rationality.

Mechanism of Action of Hedyotis diffusa Extract in a Rat Model of Acute Lung Injury Based on Transcriptomic Analysis

Simple Summary Acute lung injury has a high mortality rate, and its pathogenesis involves excessive inflammation, oxidative stress imbalance, and alveolar barrier disruption. As a traditional Chinese medicine, Hedyotis diffusa shows potential protective effects against acute lung injury; however, its specific molecular...

Preclinical investigation on the anti-atherosclerotic effects of Tenuifolin via modulation of endothelial-mesenchymal transition in animal models.

Dencichine ameliorates hepatic fibrosis by modulating the PI3K/AKT signaling pathway in cellular and murine models

Abstract: Background: Fibrotic liver is one of the serious pathophysiological consequences of chronic injury to the liver, may progress toward serious complications including cirrhosis and hepatic carcinoma. Objectives: Panax notoginseng is used for both therapeutic and prophylactic purposes in TCM; it is a source of D...

Network pharmacology and experimental verification reveal the mechanism of hederagenin in suppressing podocyte injury in focal segmental glomerular sclerosis.

BACKGROUND Podocyte injury is a pivotal driver of chronic kidney disease (CKD) progression in focal segmental glomerulosclerosis (FSGS). Although hederagenin (HDG) has shown promise in the treatment of CKD, its specific protective effects against podocyte injury in FSGS, along with its underlying pharmacological mechan...

Antifibrotic mechanism of curcumin and its therapeutic potential in multi-organ diseases

Fibrosis is the outcome of chronic diseases and manifests as an abnormal repair process in which normal parenchyma is progressively replaced by deposited extracellular matrix. It leads to organ dysfunction and is associated with high morbidity, disability, and mortality, thereby becoming a major public health concern....