TL;DR
Findings provide the first evidence linking tRF expression to varicocele and suggest a potential role for tRFs in the molecular pathology of this condition.
Background: Male infertility accounts for nearly half of all infertility cases, worldwide, and is frequently associated with molecular abnormalities that cannot be detected by routine semen analysis. Actin-like protein 7A (ACTL7A), a testis-specific actin-related protein essential for spermatogenesis, acrosome integrit...
Tyrosol notably enhanced sperm performance, suggesting its potential integration into clinical strategies for AZS management and fertility preservation and the dysregulation of the metabolite tyrosol, which is associated with AZS.
CONTEXT The epigenetic factors underlying varicocele and idiopathic infertility are still poorly understood, despite established pathophysiological mechanisms. AIMS This study assessed sperm miR-574 expression in infertile males with or without varicocele and fertile controls, evaluating its relationship with semen p...
Introduction/Objective. Male infertility accounts for approximately 40% of infertility cases, with asthenozoospermia affecting nearly one in five infertile men. Beyond conventional semen parameters, nuclear DNA organization and chromatin accessibility provide deeper insight into sperm quality. Zinc transporters ZIP6 an...
BACKGROUND Male infertility is a complex, multifactorial disorder that affects ∼7% of men worldwide. Variants in DNAH and CFAP genes are well-established causes of asthenoteratozoospermia, but the contribution of TTC-family genes (TTC12, TTC21A, TTC29) to sperm dysfunction and ICSI outcome remains poorly documented....
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