An optimised serological machine learning model enabling targeted test-and-treat for Plasmodium vivax malaria

Validation of serological markers of recent exposure to Plasmodium vivax in Cambodia: a longitudinal cohort and cross-sectional study

Summary Background Asymptomatic Plasmodium vivax infections undermine malaria control by sustaining transmission. This study aimed to validate an eight-marker serological panel (selected from 14 antigens) of P. vivax exposure to detect individuals likely harbouring hypnozoites in rural Cambodia, and to compare it with...

Diagnostics for Hemorrhagic Fever Viruses: Lassa Fever as an Example.

Lassa virus (LASV) causes severe hemorrhagic fever across West Africa where the development of rapid, accurate diagnostics remains hindered by the extensive lineage-level genetic diversity and by the limited availability of high-level containment laboratories. We developed a LASV assay using the CRISPR-based Streamline...

A machine learning approach for differential classification of chikungunya virus: an explainable AI study based on surveillance data.

Serological differentiation between Mpox infection and vaccine-induced immunity: a mini-review

In recent years, mpox has emerged as a significant global public health threat. The widespread distribution of the virus, coupled with the legacy of historical smallpox vaccination, has underscored the critical need to serologically distinguish between natural mpox infection and vaccine-induced humoral immune responses...

Reverse vaccinology approach for the design of a transmission-blocking vaccine by targeting the malaria vector Anopheles

According to the latest update from WHO, approximately 263 million cases of malaria were reported globally. The mosquito species Anopheles gambiae is the primary vector transmitting the malaria-causing pathogen Plasmodium spp. Scientists have recently focused on developing a transmission-blocking vaccine (TBV) to comba...

Modelling anti-Ov16 seroprevalence for the control and elimination of onchocerciasis

The World Health Organization aims to verify elimination of onchocerciasis transmission in 12 endemic countries by 2030. Serological assays detecting IgG4 antibodies against the Onchocerca volvulus Ov16 antigen guide decision-making regarding start- and stop-mass ivermectin treatment, post-treatment and post-eliminatio...