Jul 2026· European Open Science Space· pp. 186-191· 0 citations
TL;DR
This paper reviews the application of machine learning methods for predicting drug-resistant tuberculosis, including commonly used algorithms, data sources, performance metrics, and the major challenges associated with implementing these technologies in clinical practice.
Abstract
Drug-resistant tuberculosis (DR-TB) is one of the most serious global public health
challenges, leading to increased mortality, prolonged treatment duration, and higher
healthcare costs. Conventional methods for diagnosing drug resistance often require
considerable time, delaying the initiation of effective therapy. Recent advances in machine learning (ML) have created new opportunities for predicting drug-resistant tuberculosis
through the analysis of clinical, demographic, radiological, and genomic data. Machine
learning algorithms can identify complex patterns associated with the development of drug
resistance and assist clinicians in making faster and more informed clinical decisions. This
paper reviews the application of machine learning methods for predicting drug-resistant
tuberculosis, including commonly used algorithms, data sources, performance metrics, and
the major challenges associated with implementing these technologies in clinical practice.
The Gradient Boosting Machine (GBM) model demonstrated superior performance on the test set, and its high specificity may reduce unnecessary confirmatory testing, while its core predictors offer biological insights into TB-associated inflammatory processes.
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