Advanced Inversion Recovery Single Point Imaging for High Spatial Resolution and Quantitative Oxygen Imaging

Abstract

The partial pressure of oxygen (pO2) in tissue is a tightly regulated physiological quantity. Hypoxia is a hallmark of many diseases, and changes in tissue pO2 underline critical developmental, metabolic, and physiological processes. Electron paramagnetic resonance oxygen imaging (EPROI) has emerged as the most precise technique to image pO2 in vitro and in vivo. EPROI uses linear relationship between the relaxation rates (R1 or R2) of the spin probe OXO71 and pO2.