Aug 2026· ChemPhysChem· Vol 27 17, pp.
e202500822
· 0 citations· 40 references
Medicine
Abstract
Supramolecular hydrogels based on peptides have emerged as versatile soft materials owing to their biocompatibility, modularity, and tunable mechanical properties. To overcome the limitations of natural peptide sequences, nucleobase-peptide hybrids (nucleopeptides) have been developed, enabling coassembly and enhanced gel properties. However, their practical use requires a precise description of gelation kinetics, which remains difficult to model and predict. Herein, we apply a new rheological methodology to monitor the gelation of a specific type of supramolecular hydrogel, formulated from peptide/DNA nucleobase hybrids termed nucleopeptides. Thus, we developed an open-access program (available at https://doi.org/10.5281/zenodo.21317179) that successfully predicts the elastic moduli obtained experimentally for the four considered nucleopeptide-based hydrogels, as well as for multicomponent hydrogels formulated from nucleopeptide mixtures.
It was shown that the phase transition temperature of F127 solutions increases upon the addition of F68 or L64, enabling optimization of the gelation temperature, enabling optimization of the gelation temperature of leflunomide.
M. A. Agafonov, D. M. Panuev, I. Terekhova· Russian Journal of Physical...· 0 citations
An approach for creating self-assembling, supramolecular hydrogels based on a peptide-polymer conjugate (PPC) as a three-dimensional (3D) cell culture platform is established and a method for the encapsulation and culture of human wound healing cells, fibroblasts, within the PPC hydrogels is developed.
Breanna M. Huntington, J. Dresel, Maren Schweitzer et al.· bioRxiv· 0 citations
Nucleopeptide-based hydrogels are attracting growing interest owing to their biocompatibility and wide range of applications, particularly in biotechnology. Their enhanced versatility compared to purely peptide-based systems enables fine-tuning of macroscopic properties to meet specific requirements. However, rationa...
Corentin Boulogne, J'er'emy Morere, Noée Sigalas et al.· Journal of Physical Chemistr...· 0 citations
Nature has skillfully harnessed molecular social behavior, such as “co-assembly” and “self-sorting”, to achieve functional intricacy from simple building blocks. However, the rational control of such “social diversity” in synthetic supramolecular systems remains an unresolved problem. The entropy–enthalpy balance in hy...
Misthi Singh, Florian Trummer, Peter Schmiedel et al.· Langmuir· 0 citations
Porous materials including hydrogels offer high potential for applications requiring controlled mass transport, cell infiltration, and mechanical properties, such as tissue engineering, drug delivery, or soft robotics. We report a facile method for the synthesis of hydrogels and microgels with tunable porosity, offerin...
M. Pieper, D. D. Stöbener, B. Häßel et al.· Macromolecular rapid communi...· 0 citations
Injectable hydrogels have been recognized as an important class of soft materials for many enticing applications, yet it remains a challenge to program functions in one hydrogel substrate. Here, we report on dynamic hydrogels bearing injectable capacity and modular functionalities enabled by hydrazone formation. The hy...
