Foeniculum vulgare and metformin combination improve ovarian function in a rat model of polycystic ovary syndrome: targeting AMH imbalances, folliculogenesis disruption, fibrosis, and abnormal vascular density

Therapeutic Effect of Notoginsenoside R1 on Insulin-Resistant Polycystic Ovary Syndrome Induced by DHEA and Fructose in Female Albino Wistar Rats

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age and is characterized by hyperandrogenism, ovulatory dysfunction, insulin resistance, and metabolic abnormalities. This study aimed to evaluate the therapeutic effect of Notoginsenoside R1 in insulin-resist...

Sotalol-mediated β-adrenergic blockade restores ovarian function in an estradiol valerate–induced polycystic ovarian syndrome (PCOS) rat model: a comparative study with metformin

Evaluating the therapeutic potential of L-arginine and licorice extract in letrozole-induced polycystic ovary syndrome in rats: targeting interconnected molecular pathways

Polycystic Ovary Syndrome (PCOS) is a common disorder characterized by hyperandrogenism and ovarian dysfunction. L-arginine and licorice extract, known for their antioxidant properties, are used to manage infertility. This study aimed to evaluate the effects of licorice extract and L-arginine on ovarian morphology, ooc...

Gynura procumbens Leaf Extract Nanoparticles and Anti-Müllerian Hormone (AMH) in a Polycystic Ovary Syndrome (PCOS) Rat Model: A Systematic Literature Review of Evidence Gaps and Research Opportunities

Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder. It involves hyperandrogenism, ovulatory dysfunction, insulin resistance, low-grade inflammation, oxidative stress, and altered ovarian morphology. Anti-Müllerian hormone (AMH) is a key biomarker. It is primarily produced by granulosa cells of p...

Therapeutic Effect of Methanolic Extract of Nelumbo nucifera Leaves against Letrozole - Induced Polycystic Ovary Syndrome in Female Rats

Background: The most prevalent endocrine condition, Polycystic Ovary Syndrome (PCOS), is characterised by polycystic ovarian morphology, hyperandrogenism, and ovarian dysfunction. Anti-angiogenic, anti-cancer, anti-diabetic, anti-obesity, anti-inflammatory, antioxidant, anti-microbial, hepatoprotective, and anti-hyperl...

Synergistic Amelioration of Endocrine Dysregulation by Vernonia amygdalina and Tamarindus indica in Letrozole and Diet-induced Polyendocrine Metabolic Ovarian Syndrome in Rats

Background: Polyendocrine metabolic ovarian syndrome (PMOS) is characterised by endocrine and reproductive disturbances involving the hypothalamic–pituitary–ovarian axis. Aim: The present study aimed to evaluate the synergistic effects of Vernonia amygdalina water extract (VAWE) and Tamarindus indica methanol extract...