p140Cap enhances breast cancer chemosensitivity by limiting an ABCC1-enriched stem-like compartment via β-Catenin inhibition

Andrea Scavuzzo Matteo Poncina A. Lamolinara Alessandro Sarcinella Mahdis Jahanbin M. G. Filippone Laura Bottoni F. Tucci Yaron Vinik S. Lev Manuela Iezzi U. Ala D. Taverna F. Orso B. Belletti E. Turco S. Pece D. Tosoni Paola Defilippi Vincenzo Salemme

Aug 2026 · bioRxiv · 0 citations · 18 references

Biology

TL;DR

Clinically, analyses of breast cancer cohorts and patient-derived xenograft models identify p140Cap as predictive biomarker of chemotherapy response, proposing p140Cap-guided patient stratification, dose optimization and rational combination therapies.

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