Skip to content
Meta-analysis

Lower HLA-B27 positivity and heterogeneous late-onset case proportions across axial spondyloarthritis cohorts: a systematic review and meta-analysis

Sep 2026 · Rheumatology International · Vol 46 · 0 citations · 71 references
Medicine

TL;DR

Lower HLA-B27 positivity was the most consistent association but relied on four unadjusted comparisons and cannot be interpreted causally or diagnostically, but heterogeneity was high, the prediction interval wide, and certainty very low.

View source

Similar papers

Open access Sep 2026

Comparison of the Clinical Expression of Patients with Enthesitis/Spondylitis-Related Juvenile Idiopathic Arthritis (E/SpRJIA) from Türkiye and India

Comparisons of the clinical characteristics of enthesitis/ spondylitis-related juvenile idiopathic arthritis in Türkiye and India suggest that factors beyond HLA-B27, including broader genetic, environmental, and population-specific influences, may contribute to differences in disease expression.

R. Işgüder, Avinash Sharma, Zehra Kızıldağ et al. · 0 citations
Review Open access Sep 2026

Spondyloarthritis Research and Treatment Network Recommendations for the Referral of Adults With Chronic Back Pain and Suspected Axial Spondyloarthritis to a Rheumatologist

Objective In the United States, axial spondyloarthritis (axSpA) diagnosis is delayed up to 14 years preventing effective management. We convened a multidisciplinary clinician and patient group to develop recommendations for rheumatology referral of adults with chronic back pain. Methods Systematic review (SR) and meta‐...

Maureen Dubreuil, Abhijeet Danve, J. Liew et al. · 0 citations
Open access Oct 2026

Clinical Factors and Cumulative Smoking Burden Associated with Anti-TNF Switching in Radiographic Axial Spondyloarthritis: A Real-World Cohort Study

Background/Objectives: Anti-tumor necrosis factor (anti-TNF) switching remains common in radiographic axial spondyloarthritis (r-axSpA). We aimed to evaluate cumulative smoking burden and clinical factors associated with anti-TNF switching. Methods: This retrospective single-center cohort included 212 patients with r-a...

Ahmet Yiğitbaşı, B. Yılmazer · 0 citations
Meta-analysis Open access Sep 2026

Occurrence and clinical course of immune checkpoint inhibitor-associated inflammatory arthritis and polymyalgia rheumatica-like syndromes: a systematic review and meta-analysis

Background Immune checkpoint inhibitor-associated inflammatory arthritis (ICI-IA) and polymyalgia rheumatica (PMR)-like syndromes are clinically important rheumatic immune-related adverse events, but definitions vary across studies. We estimated their occurrence in real-world cohorts and summarized clinical course and...

Chen-Yang Li, Ru-Hui Fu, Xin-Xin Geng et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.