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TL;DR
The findings suggest that patients below the current MACS threshold may not represent a metabolically homogeneous or uniformly benign population and support further prospective investigation of cardiometabolic risk across the continuum of post-DST cortisol levels.
Higher post-DST cortisol within the suppressed range was independently associated with documented ASCVD and showed substantial discrimination, which support a cardiometabolic gradient below the mild autonomous cortisol secretion threshold but do not establish a diagnostic cutoff.
BACKGROUND Mild autonomous cortisol secretion causes substantial cardiometabolic morbidity, yet evidence for benefits following adrenalectomy remains mixed. Prior studies are limited by small sample sizes and heterogeneous definitions. This study evaluates the metabolic impact of adrenalectomy compared with nonoperativ...
Post-DST cortisol concentrations below the standard cutoff may be associated with cardiometabolic comorbidities in patients with adrenal incidentalomas, and these findings should be interpreted with caution and require confirmation in prospective studies.
Purpose Assessment of cortisol secretion in patients with adrenal incidentalomas remains challenging. We evaluated the guideline-recommended cortisol cut-off value for cortisol suppression (50 nmol/L) following a 1 mg overnight dexamethasone suppression test (DST) against a control-derived threshold and compared patien...
Comparing F-1mgDST distributions between individuals with NFAI and population-based controls and to explore whether alternative F-1mgDST thresholds would meaningfully modify patient classification found no F-1mgDST threshold with an accuracy exceeding 60% for distinguishing controls from patients with NFAI.
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