Skip to content
Log in
Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Locus-specific transposable element expression drives human hematopoietic stem cell disease pathophysiology

A. Varesi Sontago Dong Chiara Gaddoni Kerstin B. Kaufmann T. Wong I. Merelli Andy G. X. Zeng Jessica McLeod Liqing Jin Isabella di Biasio I. Novitzky-Basso J. Mattson Stephanie Z. Xie Bo-Wen Li S. Ferrari John E. Dick
Aug 2026 · bioRxiv · 0 citations
Biology

TL;DR

This study provides direct evidence that VEXAS-specific TE govern HSC clonal dominance, thereby uncovering a regulatory axis underlying HSC biology and disease mechanisms, opening a therapeutic strategy directed towards the repetitive genome.

DOI Semantic Scholar
View source

Similar papers

Open access Aug 2026

Functional restoration of immune defects in STAT1 gain-of-function disease following stem cell gene editing.

Efficient and precise correction of STAT1 GOF mutations by base editing is demonstrated, with maintenance of the correction through long-term engraftment in vivo, which represents the first application of gene editing to correct a dominant gain-of-function mutation causing immunodeficiency.

Robert Torrance, K. Orf, Nathan White et al. · 0 citations
Open access Jul 2026

A unique epigenetic circuitry defines CD8 T cell stemness shared across chronic diseases 2330201

It is found that TSC in chronic infection harbor a LEF1+ TSC pool sharing the core stemness epigenetic and molecular program observed in autoimmune LEF1+ TSC, discovering LEF1 as the master regulator defining T cell stemness and identify novel targets for therapeutic intervention.

Katrina M. Hawley, S. Miakicheva, P. Zumbo et al. · 0 citations
Jul 2026

Prdm15 deficiency perturbs hematopoietic stem and progenitor cell homeostasis.

It is reported that Prdm15 deficiency in HSPCs induces the accumulation of immature hematopoietic stem cells in mice, establishing PRDM15 as a critical epigenetic regulator of HSPCs, offering valuable insights into the molecular mechanisms underlying hematopoietic homeostasis.

Qi-Wen Dong, Wei-Wei Xiao, Junsong Huang et al. · 0 citations
Open access Aug 2026

RACK1 maintains mouse hematopoietic stem cells by directly binding to and stabilizing LDB1

Single-cell RNA sequencing indicates that adulthood Rack1 deletion in type I interferon-I-responsive cells leads to aberrant lineage-geneset-scores of transcriptional HSCs and the emergence of stressed HSCs, and Mechanistically, RACK1 prevents HSC loss through maintaining the protein level of LDB1.

L. Deng, Jun-Jie Du, Zhe Xu et al. · 0 citations
Jul 2026

In-Utero Imprinting of Gene Regulatory Networks Underpinning Innate-Like T Cell Development 2260347

Using mice carrying a mutation in the CBFβ2 isoform, it is demonstrated that CBFβ2 haploinsufficiency rewires transcriptional regulatory circuits in adult bone marrow progenitors, rendering them permissive for an early life-restricted Tγδ17 cells.

Michela Frascoli, Alyssa Berthelette, Joonsoo Kang et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.