TL;DR
Findings indicate that isoferulic acid protects against LPS/D-GalN-induced acute liver injury by reducing oxidative stress and inhibiting ERK/NF-κB and modulating NLRP3 inflammasome-associated responses.
Remifentanil attenuated LPS-induced hepatic injury, and this effect was found to be associated with modulation of oxidative stress responses, inflammatory alterations, and necroptosis-related gene expression.
BACKGROUND Itaconic acid and its isomers citraconic acid and mesaconic acid are a recently identified class of metabolites with anti-inflammatory and antioxidant effects. This study investigates their roles in ischemia-reperfusion-induced acute kidney injury. METHODS In this study, a rat model of renal ischemia-reper...
BACKGROUND Sepsis-induced acute lung injury (ALI) is a critical illness with a high mortality rate. Madecassic acid (MA), a pentacyclic triterpenoid extracted from Centella asiatica, exhibits multiple biological activities, but its role in sepsis-associated ALI remains poorly elucidated. OBJECTIVES The aim of this st...
Acute liver injury (ALI) is a severe clinical syndrome characterized by systemic inflammation and mitochondrial oxidative stress. This study investigated the hepatoprotective effects of paeonol (PA) in LPS/D-GalN-induced ALI and explored the potential involvement of macrophage mitochondrial function and NDUFS7. Proteom...
Sepsis-associated acute kidney injury (AKI) is a severe inflammatory complication with limited therapeutic options. This study investigated the protective effects of Taiwan Chingguan Yihau (NRICM101), a herbal formulation, against lipopolysaccharide (LPS)-induced AKI. Male C57BL/6 mice were injected with LPS to induce...
It is suggested that DEX attenuates HFCS-induced liver injury through a multi-target mechanism involving suppression of oxidative damage, apoptosis, and inflammasome-associated pyroptotic signaling in young adult rats.
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