Anti-Inflammatory and Hepatoprotective Effects of Solanium aethiopicum Leaf Extract in Potassium Bromate Induced Toxicity

Protective and Antioxidant Role of Flavonoids of Solanum aethiopicum Leaf in Potassium Bromate Induced Toxicity in Wistar Rats

Potassium bromate (KBrO₃) is a potent oxidizing agent that induces oxidative stress and hepatic injury. This study investigated the protective effects of flavonoids extracted from Solanum aethiopicum leaves against KBrO₃-induced alterations in liver function, antioxidant status, and lipid profile in Wistar rats. Thirty rats were randomly assigned to six groups (n = 5): normal control, S. aethiopicum flavonoids (500 mg/kg), KBrO₃ (50 mg/kg), KBrO₃ + flavonoids (250 mg/kg), and KBrO₃ + flavonoids (500 mg/kg). At the end of the treatment period, serum liver function indices, antioxidant enzymes were determined using standard biochemical methods. Potassium bromate significantly (P < 0.05) reduced serum total protein, albumin, globulin, glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT), while significantly increasing alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin, malondialdehyde (MDA). Administration of S. aethiopicum flavonoids significantly reversed these alterations in a dose-dependent manner, with the 500 mg/kg dose showing greater protective effects than the 250 mg/kg dose. The flavonoid extract restored antioxidant enzyme activities, improved liver synthetic and excretory functions. These findings demonstrate that flavonoids extracted from Solanum aethiopicum leaves possess significant hepatoprotective, antioxidant properties against potassium bromate-induced toxicity. The observed protective effects are likely mediated through free radical scavenging, preservation of hepatocyte membrane integrity, and enhancement of endogenous antioxidant defenses. Solanum aethiopicum flavonoids therefore represent a promising natural therapeutic candidate for the prevention and management of oxidative stress-mediated liver dysfunction and associated metabolic disturbances. Keywords: Hepatoprotective, antioxidants, flavonoids, Solanum aethiopicum, potassium bromate.

Comparative Hepatoprotective Effects of Carica papaya, Azadirachta indica, and Allium sativum Extracts against Diethyl Nitrosamine-Induced Liver Injury in Wistar Rats

It is indicated that combining papaya, neem, and garlic extracts may provide greater hepatoprotection than administering the individual extracts against DEN-induced liver injury, and supports further mechanistic and preclinical evaluation of this polyherbal formulation before its potential therapeutic application in liver-disease management.

Hepatoprotective effects of cinnamic acid against carbon tetrachloride–induced liver injury in a mouse model

Asiatic Acid Ameliorates Chlorpyrifos-Induced Toxicity in Rats: Biochemical and Histopathological Insights

This study provides the first demonstration that asiatic acid exerts robust systemic antioxidative, hepatoprotective, and neuroprotective effects against CPF-induced toxicity, highlighting AA’s therapeutic potential for mitigating organophosphate pesticide poisoning.

The antioxidant, anti-inflammatory and anti-apoptotic effects of Cucumis melo var. agrestis Naudin in doxorubicin-induced hepatotoxicity and nephrotoxicity in rats

CM significantly attenuates DOX-induced hepatotoxicity and nephrotoxicity, particularly at a dose of 250 mg/kg, and its protective effects are likely mediated through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.

Protective effects of Rosmarinus officinalis against methotrexate-induced hepatorenal toxicity in Wistar rats: Biochemical, histopathological, and immunohistochemical evaluation

Rosmarinus officinalis extract may exert protective effects against MTX-induced hepatorenal injury through antioxidant and anti-inflammatory mechanisms, however, further studies are required to confirm these effects and validate their therapeutic potential.