TL;DR
The diagnostic performance of the GnRH stimulation test varied with age and BMI and was lower in older girls and those with obesity, while uterine length showed relatively higher performance in girls with obesity.
Objective To evaluate long-term anthropometric, metabolic, reproductive, and bone mineral density (BMD) outcomes in girls with central precocious puberty (CPP) treated with Gonadotropin-Releasing Hormone analogues (GnRHa). Methods In this retrospective cohort with cross-sectional follow-up assessment, 82 of 265 eligibl...
The diagnosis of central precocious puberty (CPP) in girls relies on the invasive gonadotropin-releasing hormone (GnRH) stimulation test. Urinary luteinizing hormone (LH) is a noninvasive candidate biomarker, but evidence from Chinese populations and its integration into multivariable prediction frameworks remain l...
Women with PCOS demonstrated a distinct gonadotropin profile characterized by higher LH and LH/FSH ratio and lower FSH compared with healthy controls, and increasing BMI was strongly associated with lower LH concentrations and LH/FSH ratios.
Central precocious puberty (CPP) is a common pediatric endocrine disorder requiring accurate diagnosis to prevent adult height compromise and psychosocial complications. Although 2022 CPP Expert Consensus identifies gonadotropin-releasing hormone (GnRH) stimulation tests as the gold standard, its invasiveness and...
BMI SDS significantly blunts peak GH response and increases the likelihood of a GHD diagnosis, suggesting that adiposity predominantly impairs an already compromised somatotropic axis.
Central precocious puberty (CPP) is a neuroendocrine disorder resulting from premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, leading to accelerated sexual maturation and bone age advancement. A key clinical consequence is impaired growth dynamics, which may result in reduced final height. This na...
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