Aug 2026· Neurochemical Research· Vol 51· 0 citations· 49 references
Medicine
TL;DR
It is suggested that IMD-1 attenuates H2O2-induced oxidative injury in SH-SY5Y cells as evidenced by changes in oxidative stress, mitochondrial dysfunction, ATP-associated bioenergetic impairment, inflammatory mediator release, and apoptosis-related responses.
Oxidative stress and disruption of intracellular Ca2+ homeostasis contributes to dopaminergic neuronal damage in Parkinson’s disease. In this study, the protective effects of Ginkgolide B (GKB) against 6-hydroxydopamine (6-OHDA)-induced SH-SY5Y cell damage were investigated, with particular attention to oxidant-evoked...
Ramazan Çınar, Merve Göztepe, Adem Ahlatcı et al.· Current Issues in Molecular...· 0 citations
Background: Oxidative stress-mediated neuronal injury is critically involved in the pathogenesis of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. Manganese dioxide (MnO2), owing to its intrinsic reactive oxygen species (ROS)-scavenging capacity, has emerged as a promising neuroprot...
Wei-Jian Zeng, Duan-Yang Zhou, Tian-Long Wang et al.· Pharmaceutics· 0 citations
Neurodegenerative diseases represent a significant clinical challenge. Understanding the pathogenic mechanisms is essential for developing more effective therapies, and mitochondria appear to play a key role in these processes. Since current treatments are limited to symptom management, natural strategies capable of pr...
Martina Farina, G. T. Patanè, Stefano Putaggio et al.· Biomolecules· 0 citations
Genistein (GEN) exhibits concentration- and cell-type-dependent biological activities; however, the mechanisms underlying its cytotoxicity remain incompletely understood. This study investigated whether oxidative stress-mediated mitochondrial dysfunction contributes to GEN-induced apoptosis in TM4 mouse Sertoli cells a...
Samak Sutjarit, C. Sakulthaew, Nattakan Meekhanon et al.· Journal of Xenobiotics· 0 citations
Glutamate-induced excitotoxicity, characterized by oxidative stress and genomic instability, is a hallmark of neurodegenerative disorders. This study investigated the protective effects of curcumin against glutamate-induced excitotoxicity in SH-SY5Y cells, focusing on oxidative balance and DNA integrity. SH-SY5Y cells...
B. Tan, Seza Nur Suluhan, Oğuzhan Yaylalı et al.· Drug and chemical toxicology...· 0 citations
Necroptosis has been demonstrated to play a role in the process of lung ischemia‐reperfusion injury (LIRI) in a variety of clinical conditions, including cardiopulmonary bypass and pulmonary embolism. Melatonin has been reported to exert a protective role by reducing oxidative stress and acute inflammatory reactions in...
Zehra Yılmaz, Askin Tas, Ozlem Oz et al.· Cell Biochemistry and Functi...· 0 citations
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