Thermoresponsive magnetic core/shell nanoparticles were developed for controlled drug delivery in cancer therapy and doxorubicin was successfully encapsulated within the polymer shell and released upon heating above the lower critical solution temperature (LCST).
Findings demonstrate that regulating CM-Dex-MNP content provides a simple and effective strategy for simultaneously tuning LCST, magnetic properties, and drug release behavior, offering useful design principles for dual-responsive magnetic nanogel-based drug delivery systems.
Chia-Ke Tsou, Dong Fan, Wei-Jie Wang et al.· International Journal of Bio...· 0 citations
A review of the fundamental principles of magnetic hyperthermia, including heat-generation mechanisms, specific absorption rate (SAR), intrinsic loss power (ILP), AMF parameters and safety, and the interplay between Néel and Brownian relaxation is examined.
Juliana Jesus, M. Graça, A. S. Pires et al.· Nanomaterials· 0 citations
Abstract Magnetic core-shell drug-carrier microcapsules were prepared and investigated using doxorubicin (Dox) as an anticancer drug model. Superparamagnetic iron oxide nanoparticles (Fe3O4) were coated with silica SiO2 using a sol-gel method. Fe3O4@SiO2 nanoparticles were functionalized with APS to obtain Fe3O4@SiO2–N...
Samia Chalal, N. Haddadine, Taha Yakoub Bakel et al.· Journal of polymer engineeri...· 0 citations
Overall, this work presents a versatile and tunable strategy for integrating catanionic vesicles into thermosensitive polymeric scaffolds, providing a promising platform for localized melanoma drug delivery.
Rui L. Machado, Aitana Zoco, I. Oliveira et al.· ACS Applied Bio Materials· 0 citations
The developed stearic acid/lauric acid binary eutectic thermoresponsive lipid nanoparticles exhibited favorable physicochemical properties, thermoresponsive drug release, biocompatibility, and enhanced anticancer activity, highlighting their potential for thermoresponsive doxorubicin delivery in cancer therapy.
Maryam Anwar, Mubashar Rehman, Asim ur. Rehman et al.· Journal of Pharmaceutical In...· 0 citations
Overall, shell-tunable magnetic-MOF nanohybrids emerge as promising platforms for controlled, heat-free intracellular drug activation for targeted cancer therapy.
A. Panaite, A. Predeina, Aitor Alvarez Lorenzo et al.· Small· 0 citations
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