TL;DR
Hydrodynamic shear and medium ionic strength jointly influence ASD supersaturation and precipitation behavior and their simultaneous consideration may improve the biorelevance of ASD dissolution testing.
The solid dispersion of ABA with HPMCAS-LF significantly improved solubility, dissolution, and diffusion, highlighting its potential for enhanced oral bioavailability and improved therapeutic outcomes.
A thermoresponsive solid dispersion containing atorvastatin calcium enhances dissolution performance and eliminates the need for organic solvents through simple manufacturing processes.
Diosmetin (DM) is a natural flavonoid with poor water solubility and low bioavailability. This study aimed to improve the dissolution of DM by preparing amorphous solid dispersions (ASDs) using hot melt extrusion (HME) with chitosan lactate (CL) and polyvinylpyrrolidone K30 (PVP-K30). The processability of the formulat...
The aim. The aim of the work is to study the effect of hydrophilic polymers (PVP K-12, PVP K-17, HPC) and excipients (sucrose, mannitol) on rivaroxaban supersaturation, as well as to apply thermodynamic modeling to determine the optimal composition and evaluate the robustness of ternary solid dispersion systems (SDS)....
The solubility advantage of an amorphous drug can be realized only when it releases at a sufficiently rapid rate from its amorphous solid dispersion (ASD). Herein, we evaluated the impact of a plasticizer, glyceryl tributyrate (GTB), on the release of a poorly soluble drug with a high glass transition temperature (Tg...
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