TL;DR
The COX-2 -765G>C polymorphism, as an inflammatory mediator-related variant, had no effect on the risk of diabetes or its complications.
BACKGROUND Diabetic nephropathy (DN) is one of the most common microvascular complications of type 2 diabetes mellitus (T2DM) and a leading cause of chronic kidney disease worldwide. Inflammatory pathways play a key role in the pathogenesis and progression of DN. Interleukin-8 (IL-8), a pro-inflammatory cytokine involv...
Type 2 diabetes mellitus (T2DM) is a complex, multifactorial metabolic disease that involves a number of interactions between genetic and environmental factors. There are gene variants that are involved in insulin secretion control including KCNJ11 which have been found to contribute to the susceptibility of T2DM in di...
Despite a high incidence of laboratory-defined aspirin resistance among this cohort, the COX-2 rs689466 polymorphism was not significantly associated with Aspirin resistance, suggesting the need for individualized antiplatelet therapy.
Adiponectin receptor 2 (ADIPOR2) contributes to adiponectin-mediated glucose and lipid metabolism. This case–control study investigated whether the ADIPOR2 single-nucleotide polymorphism (SNP) rs16928751 (+795 G/A) was associated with type 2 diabetes mellitus (T2DM) in an Iraqi study population. The study included 48 p...
Background: Hypertension (HTN) is a major global health issue influenced by genetic, environmental and demographic factors. The angiotensin-converting enzyme 2 (ACE2), important for blood pressure regulation, has been linked to HTN in different ethnic populations, but research among the southern Bangladeshi population...
Background: Hypertension is a condition characterized by elevated blood pressure, posing a risk factor for various cardiovascular diseases (CVDs) with increasing prevalence worldwide. One risk factor for hypertension includes single nucleotide polymorphism (SNP) A1166C (rs5186) in angiotensin II type 1 receptor (AT1R)...
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