KIKUCHI-FUJIMOTO DISEASE IN A YOUNG WOMAN: A RARE CAUSE OF CERVICAL LYMPHADENOPATHY

Abstract

Background: Kikuchi-Fujimoto disease (KFD) is an infrequently encountered, self-resolving lymph node pathology predominantly seen among young females. In regions with high tuberculosis burden, its clinical manifestations frequently overlap with tuberculous lymphadenitis, creating diagnostic uncertainty and potentially resulting in unwarranted anti-tubercular pharmacotherapy. Case Presentation: We describe a 24-year-old female who presented with right cervical lymph node enlargement accompanied by high-grade pyrexia, generalized weakness, unintentional weight reduction, and diminished appetite. Laboratory evaluation demonstrated leucopenia (WBC 3700/µL) alongside raised ESR (40 mm/hr). QuantiFERON-TB Gold assay yielded negative results. Excisional lymph node biopsy was performed, and AFB staining and GeneXpert MTB/RIF assay on the biopsy specimen were negative. Histopathological examination revealed hallmark features of KFD, including necrotic zones containing karyorrhectic debris enveloped by histiocytic and plasmacytoid cellular infiltrates. Serological markers for autoimmune disease were unremarkable. The patient received conservative management and achieved complete clinical and sonographic resolution over a 6 -month observati on period.