Impact of preoperative frailty and sarcopenia on short-term functional recovery after cardiac surgery in elderly patients: a prospective cohort study.
Abstract
Background
Preoperative sarcopenia and frailty are associated with poor outcomes in elderly patients undergoing cardiac surgery; this study aimed to investigate the effects of sarcopenia and frailty on postoperative recovery in elderly patients.
Methods
This prospective cohort study included 566 patients aged ≥60 years with an American Society of Anaesthesiologists (ASA) II-IV status who were scheduled for elective open-heart surgery between June 30, 2024, and April 5, 2026. Frailty was assessed using the Comprehensive Geriatric Assessment Frailty Index (CGA-FI). Sarcopenia was diagnosed based on the CT-based skeletal muscle index (SMI), grip strength, and physical function. The primary outcome was worsening disability or death within 3 months after surgery.A multivariate logistic regression model was used to estimate the association of sarcopenia and/or frailty with worsening disability or death within 3 months after surgery.
Results
Patients with sarcopenia and frailty did not experience a reduction in disability burden within 3 months postoperatively [-2.0 (IQR: -9.0, 21.2)]. In contrast, patients with sarcopenia only and those with frailty only had significant reductions in the overall disability burden [-5.0 (IQR: -7.0, 0.0) and -5.0 (IQR: -8.0, -1.0)]. Compared with normal patients, those with both sarcopenia and frailty (OR = 3.09; 95% CI 1.61-5.96), those with sarcopenia only (OR = 2.65; 95% CI 1.38-5.12), and those with frailty only (OR 1.93; 95% CI 1.01-3.72) had a significantly increased risk of worsening disability or death within 3 months post-surgery.
Conclusion
Frailty, sarcopenia, and their combination are associated with a significantly increased risk of worsening disability or death within 3 months after surgery. Notably, compared with patients with both sarcopenia and frailty, those with frailty alone or sarcopenia alone have a lower burden of postoperative disability.