A behavioral paradigm is developed to measure and influence participants' decision-making and perception in two distinct perceptual tasks and shows that, under uncertain conditions, feature interference causes errors by inducing stronger representations of irrelevant features and entangled neuronal representations of different features.
Mice are widely used to study the neural basis of perceptual decision-making, often with the ultimate goal of extrapolating insights to humans. Yet, whether humans and mice rely on similar computational strategies remains rarely tested, partly because the two species acquire knowledge differently. Animals learn from ex...
I. Hoxha, Philippa A. Johnson, Fen-Ying Zang et al.· bioRxiv· 0 citations
While humans resemble other primates in terms of motor and perceptual abilities, our behavior is uniquely characterized by morality—the ability to choose our actions based on specific ethical values. The evolutionary origins and neurobiological basis of moral behavior are debated intensely, with opposing proposals abou...
Rui-Da Zhu, Marcus Grueschow, M. Moisa et al.· PLoS Biology· 0 citations
Flexible behavior in complex environments requires animals to infer which sensory inputs are relevant for guiding action and which need to be ignored. Yet, how cognitive control circuits apply contextual knowledge during decision-making is poorly understood. To address this question, we trained head-fixed mice on a cro...
K. Safaryan, Rohan Bhalodia, Jonathan Shenassa et al.· bioRxiv· 0 citations
Functional digital twins found that when and whether a surround facilitates or suppresses the optimal center feature depends on how congruent the surround is given that feature under natural scene statistics, consistent with hierarchical Bayesian inference.
H. Mansvelder, A. Kreiter, Ziad M. Hafed et al.· 0 citations
Flexible behavior depends on continuous updating of internal models, yet the neural circuits coordinating this process remain poorly understood. The claustrum, which is reciprocally connected to nearly the entire neocortex, is uniquely positioned to influence cortical processing. Here we report single-neuron recordings...
Our knowledge of the neural basis of sensory and motor information processing comes largely from recording brain activity in controlled settings. This approach, while insightful, blinds us from understanding natural behaviors, which involve far richer visual inputs and far larger range of movements. The prevailing beli...
