AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
DLL4⁺ neutrophils are identified as key orchestrators of macrophage dysregulation in sepsis-induced ALI and NDI may represent a potential therapeutic candidate in sepsis-induced ALI.
BACKGROUND Impaired clearance of apoptotic neutrophils by alveolar macrophages (AMs) may sustain inflammation in acute lung injury (ALI). Although PKM2 regulates macrophage inflammatory responses, its relationship with AM efferocytic dysfunction during ALI remains unclear. METHODS We integrated time-course single-cel...
Sepsis-induced acute lung injury (SALI) is an important complication of sepsis associated with substantial morbidity and mortality, yet effective targeted therapies remain limited. Neutrophils are central effectors of innate immunity and play indispensable roles in early antimicrobial defense. However, during sepsis, p...
Progressive pulmonary fibrosis (PPF) is a fatal lung condition characterized by persistent inflammation and progressive fibrotic remodeling. Monocyte-derived alveolar macrophages (Mo-AMs) are key drivers of fibrogenesis; however, the mechanisms underlying their persistence in fibrotic lungs remain unclear. Using lineag...
Sterile tissue injury triggers a rapid neutrophil response that can be either pathogenic or protective, reflecting substantial functional heterogeneity of neutrophils; however, the neutrophil subsets underlying these divergent functions remain poorly defined. Here, using a well-established sterile corneal injury model,...
SJS attenuated LPS-induced ALI and restrained neutrophil activation and NET formation mediated by C5a/C5aR1 signaling, and Ferulic acid was identified as a candidate circulating constituent that reduced C5a-activated NET formation.
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