Mar 2026· Caspian Journal of Internal Medicine· Vol 17, pp. 302 - 311· 0 citations· 40 references
Medicine
TL;DR
Older people with osteopenia, osteoporosis and fracture had lower visceral fat mass, lean mass, lean mass and waist circumference than normal people and LM, WC and VFM had the greatest effect on BMD and fracture in elderly diabetic.
Abstract
Background: Diabetes is a common metabolic disorder and one of its comorbidities is osteoporosis. In previous studies, the effect of lean mass and fat mass on bone has been investigated separately. Therefore, the aim of this study was to investigate the association between body composition with bone mineral density (BMD) and fractures in diabetic elderly. Methods: This population based cross-sectional study is part of the second phase of the Amirkola Health and Ageing Cohort Project (AHAP). Diabetes was diagnosed by fasting blood glucose level twice greater than or equal to 126 mg/dl. BMD and body composition were measured by Hologic Horizon-WI densitometer. History of fracture was obtained by asking the elderly individual. Then data were analyzed using statistical tests and ROC curve. Results: Out of 469 elderly diabetics, 270 (57.57%) were women. The mean age was 68.70±6.18. Older people with osteopenia, osteoporosis and fracture had lower visceral fat mass (VFM), lean mass (LM) and waist circumference (WC) than normal people. The mean BMD in elderly with less than 10 years of diabetes history was greater and the percentage of fractures in elderly individuals with more than 10 years of diabetes was higher. In Roc analysis, the highest area under the curve was related to LM 78% (0.78±0.02), WC 67% (0.67±0.03) and VFM 62% (0.62±0.03) for estimation of osteoporosis. Conclusion: In this study, LM, WC and VFM had the greatest effect on BMD and fracture in elderly diabetic.
Increases in ECF, ICF, and TBW were significantly linked to a lowered osteoporosis risk and enhanced BMD, which may aid clinicians in the early identification and intervention of patients at risk for bone loss.
Wanxin Su, Sizhe Xiao, Yanhui Li et al.· American Journal of the Medi...· 0 citations
Higher HbA1c levels were associated with lower bone mineral density categories in an exploratory regression model adjusted for the variables included in the analysis and support further investigation of the relationship between glycaemic control and bone health in larger prospective studies with comprehensive adjustment for clinical confounders.
H. Alharbi, A. Mohammed, Sahar Mohammed Alatni et al.· BMC Endocrine Disorders· 0 citations
To investigate the association between the Metabolic Score for Insulin Resistance (METS-IR) and bone mineral density (BMD) and trabecular bone score (TBS) in adult cancer patients.
This cross-sectional study enrolled 127 patients (median age 63 years, 44.9% female) with histopathologically confirmed malignancies. BMD at the lumbar spine, femoral neck, and total hip and lumbar spine TBS were measured by dual-energy X-ray absorptiometry. METS-IR was calculated using fasting glucose, triglycerides, high-density lipoprotein cholesterol, and body mass index. Multivariable linear regression was used to identify independent associations.
After adjustment for confounders, METS-IR was independently and positively associated with BMD at lumbar spine (β = 0.006, 95% CI 0.002–0.011, P = 0.007), femoral neck (β = 0.007, 95% CI 0.003–0.011, P < 0.001), and total hip (β = 0.007, 95% CI 0.003–0.010, P < 0.001). Age was inversely associated with lumbar spine and femoral neck BMD, but not with total hip BMD; bone metastasis was linked to higher lumbar spine and total hip BMD. In contrast, METS-IR showed no significant association with lumbar spine TBS (P = 0.374). For TBS, age and male sex, but not METS-IR, were independent determinants.
In cancer patients, higher METS-IR is independently associated with greater BMD but not with better trabecular microarchitecture. This discordance between bone quantity and quality suggests that insulin resistance may mask impaired bone quality despite preserved BMD. Clinicians should consider bone quality assessments when evaluating fracture risk in metabolically compromised cancer patients. Longitudinal studies are warranted to confirm these findings.
Hong-Dan Yao, Cheng Niu, Lin Zhu et al.· Frontiers in Endocrinology· 0 citations
Type 1 diabetes mellitus patients showed a markedly higher prevalence of vertebral fractures and lower femoral neck BMD compared with healthy controls, suggesting a potential role of phosphate metabolism in diabetic bone fragility.
Hatice Gizem Günhan, Okan Çetin, Eren İmredrg et al.· Cerrahpasa Medical Journal· 0 citations
Patients with obesity demonstrated site-specific reductions in trabecular bone quality, particularly in the lower lumbar spine compared with non-obese people, suggesting that metabolic dysfunction, not mechanical loading, influences bone fragility in obesity.
Taehoon Park, K. Seo, Ki Hyun Kim et al.· Endocrinology and Metabolism· 0 citations
