TL;DR
How under normal physiological conditions or in certain diseases, PS exposure on the cell membrane surface, through specific cell receptors or circulating proteins, induces a cascade of biological reactions is described.
Strong physiological activation of blood platelets leads to the emergence of a non-aggregatable procoagulant subpopulation characterized by the appearance of phosphatidylserine on the outer leaflet of the plasma membrane, providing a surface for coagulation reactions. The formation of procoagulant platelets is attribut...
It is proposed that phagolysosomal membrane disorganization by GBP1 allows pore formation by APOL3, through transmembrane insertion and cardiolipin solubilization in the inner coating of phagolysosomal membrane megapores.
Cell-surface gangliosides tune receptor signaling, cell-state transitions, and responses to stress. NEU3 is a mammalian sialidase associated with the plasma membrane and endomembranes that preferentially removes terminal sialic acids from gangliosides. Here, we critically review biochemical studies, cultured-cell exper...
With the exception of tractopods, all PMPTs - including PITTs and FLIPRs - support leukocyte adhesion, thereby influencing immune cell recruitment and activation, and strongly indicates a role of PMPTs in the crosstalk between hemostasis and inflammation.
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