Peritoneal Carcinomatosis as A Remaining Challenge of Abdominal Oncology: Contemporary Possibilities of Combined Modality Treatment

Abstract

The present paper reviews the literature data on the current state of peritoneal carcinomatosis treatment. The international oncological associations of NSSN, ESMO, and AJCCA recommend chemotherapy to treat peritoneal carcinomatosis as a distant metastasis of malignant tumors. In recent years, the issues of combined modality treatment using various methods of locoregional impact have been widely discussed. The introduction of a new treatment strategy of “conversion surgery” based on cytoreductive operations has become a promising direction in the treatment of patients with peritoneal carcinomatosis. The effectiveness of systemic chemotherapy administered both as preoperative induction chemotherapy and in combination with surgical treatment methods, intraperitoneal hyperthermic chemotherapy, pressurized intraperitoneal aerosol chemotherapy, and peritonectomy is analyzed. The small sample of patients included in the study, as well as conflicting data on the effectiveness of these methods significantly complicate the reliability assessment of obtained results and necessitate the conduct of large-scale prospective randomized controlled trials with the scientific analysis of obtained results.