Maresin1 Improves Angiogenesis and Cognitive Function by Regulating Perivascular Macrophages in Rats with Chronic Cerebral Hypoperfusion

Emodin Suppresses the RAGE/ROCK1 Pathway to Modulate the Oligodendrocyte Lineage and Ameliorate Demyelination in Vascular Dementia Rats

Vascular dementia (VD), a prevalent cognitive disorder mainly resulting from chronic cerebral hypoperfusion‐triggered white matter injury (WMI), takes regulation of oligodendrocyte (OL) lineage and restoration of remyelination as key therapeutic targets, whereas the precise role and mechanism of the natural neuroprotec...

Microglial P2Y12 Drives Chronic Cerebral Hypoperfusion via Ca2+ Activity-Mediated Neuroinflammation and Vascular Injury.

BACKGROUND Chronic cerebral hypoperfusion is a major driver of vascular cognitive impairment (VCI), but the role of microglial purinergic signaling in chronic cerebral hypoperfusion-induced neurovascular dysfunction remains undefined. This hypothesis-testing study with a novel research premise aimed to address this kno...

Attenuation of Vascular Cognitive Impairment by Panaxadiol Through Promoting Hippocampal Angiogenesis in a Chronic Cerebral Hypoperfusion Model.

OBJECTIVE This study explores the therapeutic efficacy and mechanisms of panaxadiol (PD), a ginseng-derived sapogenin, in a mouse model of vascular cognitive impairmentinduced by chronic cerebral hypoperfusion (CCH). METHODS CCH was induced in C57BL/6 mice by bilateral common carotid artery stenosis (BCAS). Mice were...

Pathophysiological Role of Perivascular Macrophages in Blood–Brain Barrier Dysfunction Induced by Cerebral Hypoperfusion in Mice

This study investigated the role of perivascular macrophages (PVMs), localized alongside the brain vasculature, in blood-brain barrier (BBB) dysfunction induced by reduced cerebral blood flow (CBF). Using a mouse model of bilateral carotid artery stenosis (BCAS) to examine cerebral hypoperfusion, the effects of pharmac...

Modified Dioscorea pills ameliorate cognitive impairment induced by chronic cerebral hypoperfusion via restoring the hippocampal neurovascular unit

Chronic cerebral hypoperfusion (CCH) is a major cause of progressive cognitive decline and vascular dementia in older adults. Modified Dioscorea Pills (MDP), a traditional Chinese medicinal formula, has demonstrated clinical efficacy for dementia treatment. However, the effects and molecular mechanisms of MDP on th...

Da chuanxiong formula improves vascular remodeling via promoting angiogenesis and vasodilation mediated by PI3K/Akt/eNOS signaling