Syringic acid attenuates chlorpyrifos-induced redox imbalance, mitochondrial depolarization, and apoptosis-related transcriptional changes in HepG2 cells.

Oxidative Stress-Mediated Mitochondrial Dysfunction Drives Genistein-Induced Apoptosis in TM4 Sertoli and ELT3 Leiomyoma Cells

The findings support a ROS-dependent mitochondrial apoptotic response under elevated in vitro GEN exposure but do not establish selective antitumor cytotoxicity or direct physiological relevance.

SALVIANOLIC ACID B ATTENUATES GLUCOLIPOTOXICITY-INDUCED OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION IN AML12 HEPATOCYTES VIA MODULATING CRBN/AMPK SIGNALING

It is suggested that SalB protects hepatocytes from glucolipotoxic injury by limiting oxidative damage, preserving mitochondrial function, and restoring CRBN-associated AMPK signaling.

Disruption of Mitochondrial Bioenergetics Links Oxidative Stress-Mediated Apoptosis to Hepatorenal Injury Following Sub-Chronic Exposure to Titanium Dioxide Nanoparticles

Titanium dioxide nanoparticles (TiO2-NPs) are widely used nanomaterials, but their potential systemic toxicity following chronic exposure remains a significant concern. This study investigated whether mitochondrial dysfunction represents a key mechanistic link between oxidative stress, apoptosis, and organ injury induc...

ROS-mediated autophagy-apoptosis crosstalk regulates cell fate in the marine microalga Isochrysis galbana under BDE-47 stress.

Although the regulatory crosstalk between autophagy and apoptosis in response to stress has been well documented in higher multicellular eukaryotes, its functional significance in marine microalgae exposed to persistent organic pollutants (POPs) remains largely unclear. Here, we investigated the coordinated responses o...

Acetochlor Induces Nephrotoxicity in Chicken through IP3R1-GRP75-VDAC1-Mediated Stabilization of Mitochondria-Associated MAMs and the Regulation of Apoptosis and Autophagy, an Effect That Is Mitigated by Omega-3 Fatty Acids.

Acetochlor (ACT)-induced nephrotoxicity in poultry remains poorly understood. This study investigated the renal toxicity of ACT in chickens and evaluated the protective effects of Omega-3 supplementation using molecular dynamics simulations, Western blotting, and immunofluorescence staining. Prolonged ACT exposure indu...

Redox Imbalance, Oxidative DNA Damage, and Mitochondrial Membrane Depolarization Induced by Pervari Honey in SH-SY5Y Neuroblastoma Cells