Jul 2026· Ophthalmic Surgery Lasers and Imaging Retina· Vol 57, pp.
1-5
· 0 citations· 14 references
Medicine
TL;DR
Elevated IGF-1 levels in CSCR patients suggest that this growth factor may contribute to disease pathogenesis through mechanisms involving choroidal vascular permeability and retinal endothelial activity.
Abstract
Background
AND
Objective
This study aimed to investigate serum levels of insulin-like growth factor-1 (IGF-1) and its association with parameters related to insulin resistance, in patients diagnosed with central serous chorioretinopathy (CSCR).
PATIENTS AND
Methods
In this cross-sectional comparative study, patients were classified as simple (n = 30) or complex (n = 25) CSCR based on multimodal imaging findings. Following a comprehensive ophthalmologic examination, fasting venous blood samples were collected for the biochemical analysis of glucose, insulin, IGF-1, C-reactive protein (CRP), and glycated hemoglobin (HbA1c). Subsequently, body mass index (BMI) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) values were calculated for each participant.
Results
Mean serum IGF-1 levels were significantly higher in simple and complex CSCR groups compared with controls (P < .05). No significant differences were observed among the groups in glucose, HbA1c, CRP, BMI, or HOMA-IR (P > .05).
Conclusion
Elevated IGF-1 levels in CSCR patients suggest that this growth factor may contribute to disease pathogenesis through mechanisms involving choroidal vascular permeability and retinal endothelial activity.
Findings indicate significant changes in the IGF system in patients with T1D, and changes in IGF-1 and IGF-2 levels are thought to be related to the metabolic disturbances seen in T1D.
E. M. Eltayef, K. Gharab, L. Ghannawi et al.· Diabetes mellitus· 0 citations
The current study was designed to explore the association between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and vitamin D with the cause and development of diabetic retinopathy (DR) in Iraqi patients. The study included ninety males, separated into two categories.: Thirty controls and sixty patients (30 DR with 30 NDR). The outcomes showed that DR and NDR had higher mean HbA1c levels of 9.583 ± 0.35% and 8.713 ± 0.32%, respectively. While the vitamin D levels showed no significant difference between the three groups, IGF-1 also revealed quite notable variations. At (p<0.001) between the 2 groups. There was less IGF-1 present in Type 2 Diabetes mellitus (T2DM) and greater within the control group. GH showed the highest level of GH in the DR compared with the control and NDR. Additionally, the results indicated that BMI did not impact HbA1c (p < 0.2620). And GH (p < 0.884), respectively, while it did influence vitamin D (p < 0.009) and IGF-1 (p < 0.016), respectively. Age had a significant impact on both IGF-1 (p < 0.016) and HbA1c (p < 0.006), respectively, while it showed no impact on vitamin D at p < 0.262 and GH at p < 0.61
Maha R. Ghreeb, M. Q. Al-Ani, Huda M. Mahmood· Iraqi Journal of Science· 0 citations
AIMS/BACKGROUND
Obesity in children was associated with insulin resistance (IR) and is often accompanied by dyslipidemia. 25-hydroxyvitamin D (25-(OH)D) and insulin-like growth factor-1 (IGF-1) have been implicated in IR. The purpose of this study was to explore the correlation between IR and serum 25-(OH)D, IGF-1, and blood lipid profiles in children with obesity.
METHODS
A total of 125 children with obesity who attended The Affiliated Yangming Hospital of Ningbo University between January 2023 and April 2025 were retrospectively analyzed. According to insulin sensitivity, participants were divided into two groups: the insulin-sensitive group (n = 56, Homeostasis Model Assessment of Insulin Resistance [HOMA-IR] <3.16) and the insulin-resistant group (n = 69, HOMA-IR ≥3.16). Serum 25-(OH)D, IGF-1, and lipid profiles [triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)] were measured. Binary logistic regression analysis and receiver operating characteristic (ROC) analyses were performed to investigate the association between IR and these biomarkers.
RESULTS
Fasting insulin and HOMA-IR levels were significantly higher in the insulin-resistant group than in the insulin-sensitive group (p < 0.001). Compared with the insulin-sensitive group, levels of 25-(OH)D, IGF-1, and HDL-C were significantly lower in the insulin-resistant group (p < 0.001, p = 0.032, and p = 0.023, respectively), while TG and LDL-C levels were significantly higher (p < 0.001). No significant difference was observed in TC levels between the two groups (p = 0.334). Multivariate analysis identified 25-(OH)D (odds ratio [OR] = 0.934, 95% confidence interval [CI]: 0.877-0.995, p = 0.035), IGF-1 >238.68 (OR = 0.303, 95% CI: 0.103-0.894, p = 0.031), TG (OR = 3.979, 95% CI: 1.461-10.835, p = 0.007), and LDL-C (OR = 2.625, 95% CI: 1.398-4.928, p = 0.003) as independent factors associated with IR in children with obesity. ROC analysis showed that the areas under the curves (AUCs) for 25-(OH)D, IGF-1, TG, LDL-C, and the combined indicator were 0.692, 0.612, 0.775, 0.747, and 0.856, respectively (p < 0.001, p = 0.025, p < 0.001, p < 0.001, and p < 0.001).
CONCLUSION
In children with obesity, serum 25-(OH)D, IGF-1, TG, and LDL-C are significantly associated with IR.
Unknown authors· British journal of hospital...· 0 citations
C-peptide can be used as an appropriate index for identifying IR in T2DM patients with complications and illustrated the clinical utility of C-peptide in microvascular complications such as diabetic nephropathy and diabetic retinopathy.
K. Siddiqui, S. Joy, S. Nawaz et al.· Medicine· 0 citations
Teprotumumab N01 treatment was associated with a substantial, early, and broadly reversible increase in circulating IGF-1 in patients with moderate-to-severe TED, but IGF-1 dynamics did not serve as an independent indicator of glycemic deterioration.
Wei Zhao, Lingli Zhou, Ying Gao et al.· Frontiers in Endocrinology· 0 citations
BACKGROUND
Diabetic kidney disease (DKD) is a major complication of type 2 diabetes (T2D). Fibroblast growth factor 19 (FGF19) is a key metabolic regulator, but its relationship with DKD, as defined by estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR), remains unclear.
METHODS
This cross-sectional study included 330 T2D inpatients and 60 normal controls (NC group). Serum FGF19 levels were measured by ELISA. Renal function was evaluated according to eGFR (CKD-EPI equation) and UACR. Associations between FGF19 levels and renal parameters were analyzed according to Spearman's correlation, partial correlation, and multiple linear regression analyses adjusted for confounders.
RESULTS
Serum FGF19 levels were lower in the T2D group than in the NC group (110.25 [68.40-169.32] vs. 242.06 [143.74-319.51] pg/mL, p < 0.001). Among those with T2D, patients with DKD had higher FGF19 levels than those without DKD (122.61 [83.38-189.02] vs. 106.97 [66.54-164.22] pg/mL, p = 0.023). In T2D patients, FGF19 was positively correlated with UACR (r = 0.185; p = 0.005) and inversely correlated with eGFR (r = -0.210; p = 0.001), and these correlations persisted after adjustment for confounders. In fully adjusted linear regression models, FGF19 remained independently associated with a higher UACR (β = 0.203, t = 2.286, p = 0.024) and a lower eGFR (β = -0.170, t = -2.542, p = 0.012). Restricted cubic spline analyses confirmed linear relationships between lnFGF19 and both lnUACR (p = 0.480) and eGFR (p = 0.162).
CONCLUSION
Serum FGF19 levels are independently associated with DKD status in T2D patients; the serum FGF19 level is decreased in T2D patients but relatively elevated in those with DKD. FGF19 levels are independently associated with a higher UACR and a lower eGFR. Restricted cubic spline analyses confirmed linear, rather than nonlinear, associations. These cross-sectional findings suggest an association between FGF19 and diabetic kidney pathology, though the modest effect sizes and study design limit causal interpretation.
