Improved Autism Spectrum Disorder Detection Using Euclidean-Distance Facial Landmark Features to Enhance Classification Accuracy and Stability with Cross-Validation
Findings indicate that geometric feature extraction based on facial landmark distances is effective for ASD detection and has strong potential to be developed as an objective, interpretable, and efficient early screening tool using children’s facial images.
Abstract
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that affects communication skills, social interaction, and behavioral patterns. Early detection is essential for timely intervention; however, conventional diagnostic methods remain time-consuming and subjective, as they rely heavily on clinical observations and expert judgment. This limitation highlights the need for an automated and objective approach to support early ASD screening. This study aims to analyze the performance, stability, and generalization of ASD classification using geometric features extracted from distances between facial landmarks. By representing facial morphology in terms of quantitative spatial relationships, this approach provides a more interpretable alternative to raw image-based methods. This study contributes by proposing a geometric feature representation based on facial landmark distances, providing a comparative analysis between linear and nonlinear classifiers, and ensuring robust evaluation through cross-validation. The dataset consists of 2,032 facial images, evenly distributed between children with ASD and those with typical development. A total of 68 facial landmark points were detected and used to compute pairwise Euclidean distances as classification features. Two classification algorithms, Logistic Regression and Extra Trees Classifier, were evaluated using 5-fold cross-validation to ensure reliable and unbiased performance estimation. The results show that Logistic Regression achieved an average accuracy of 89.91%, precision of 91.04%, recall of 88.56%, and F1-score of 89.76%. Meanwhile, the Extra Trees Classifier outperformed the linear model, achieving an average accuracy of 91.88%, precision of 92.69%, recall of 90.89%, and F1-score of 91.77%. Overall, both models demonstrated stable and consistent performance across validation folds, with the Extra Trees Classifier showing superior ability to capture nonlinear patterns in the data. These findings indicate that geometric feature extraction based on facial landmark distances is effective for ASD detection and has strong potential to be developed as an objective, interpretable, and efficient early screening tool using children’s facial images.
The proposed VGG16-based approach has potential as a supportive, non-invasive tool for early ASD screening and is deployed as an interactive, Streamlit-based web application that allows users to upload facial images and receive real-time predictions.
A comprehensive machine learning framework to classify ASD severity (mild, moderate, severe) is developed and validates by investigating the differential impact of feature engineering and selection, revealing a critical “evaluation paradox” where radical, unguided feature reduction improved geometric cluster cohesion but degraded clinical accuracy.
Arazo Mohammed Mustafa· ARID International Journal f...· 0 citations
The application of data mining technologies in the early identification of children with Autism Spectrum Disorder (ASD) has gained prominence. Facial image analysis has emerged as a popular method for its efficiency and scalability. However, current approaches often classify facial images into ASD categories without elucidating the specific contributions of different facial areas to the outcomes. To address this gap, we propose a novel method for ASD detection using facial images while concurrently identifying significant facial areas. Our approach integrates a Pre-trained Image Encoder to extract semantic information from the original image, a Gated Fusion Module to dynamically regulate the contribution of each pixel, and a scoring layer to predict ASD scores based on the fused feature map. Experimental validation on a publicly available dataset showcases the efficacy of our method, demonstrating commendable performance in terms of precision and recall metrics.
Mangna Fang, Yangyang Fang, Ran Wei et al.· International Conference on...· 0 citations
Objective and non-invasive markers for psychiatric assessment remain limited. This study evaluated whether standardized tongue and facial color features provide measurable information relevant to depression and schizophrenia classification. Tongue and facial images were collected from 749 participants, including healthy controls (n = 84), patients with depression (n = 246), and patients with schizophrenia (n = 419). Color characteristics were quantified in predefined tongue and facial regions using the LAB color space. Group differences were examined statistically, and machine-learning models were evaluated across five repeated stratified splits. Most LAB-derived features differed significantly across groups, with luminance-related measures showing the largest effect sizes and more consistent shifts in schizophrenia than in depression. In multiclass classification, LAB plus demographic variables achieved strong performance (accuracy = 0.782 ± 0.035, macro-F1 = 0.697 ± 0.038, AUC = 0.912 ± 0.027), similar to LAB plus demographic and traditional variables (AUC = 0.912 ± 0.032). LAB-only models showed comparable AUC to demographic-only models but lower macro-F1. In pairwise analyses, discrimination was strongest for healthy control versus schizophrenia (AUC = 0.952 ± 0.030) and depression versus schizophrenia (AUC = 0.926 ± 0.019), and lower for healthy control versus depression (AUC = 0.817 ± 0.054). These findings suggest that LAB-derived tongue and facial color features may provide complementary group-level information, particularly when combined with demographic variables, but should not be interpreted as standalone diagnostic biomarkers.
Li-Min Gao, Meng-Meng Zhang, Yuanhao Li et al.· Behavioral Science· 0 citations
These findings demonstrate the potential of computer vision-based analysis of children’s expressive activities as an effective, non-invasive ASD pre-screening tool and will focus on expanding dataset diversity and integrating multimodal behavioral cues to improve model generalization and clinical applicability.
Aina Khairina Ahmad Khair, Wan Mohd Yaakob Wan Bejuri, Mohd Murtadha Mohamad et al.· Bulletin of Electrical Engin...· 0 citations
Experimental results demonstrate that the Random Forest model achieved an accuracy of 96.8%, while the ResNet18 model attained 94.2% accuracy, indicating the effectiveness of combining behavioral and facial information for preliminary ASD screening.
Neha A. Kandalkar, R. Jogekar· Adolescência e Saúde· 0 citations
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