Sep 2026· International Journal of Advanced Research· 0 citations
TL;DR
The findings supported two synchronous primary tumors rather than metastatic breast cancer, and two synchronous primary tumors rather than metastatic breast cancer.
Abstract
Background: Gastrointestinal stromal tumors (GISTs) may coexist with other primary malignancies, but synchronous invasive breast carcinoma and gastric GIST remain rarely reported. Case presentation: A 71-year-old postmenopausal woman presented with a palpable left-breast nodule. Mammography and ultrasonography showed a 15 - 10 mm irregular spiculated ACR 5 lesion. Core-needle biopsy demonstrated grade 2 invasive breast carcinoma. Staging thoracoabdominopelvic CT unexpectedly revealed a 107 - 108 mm heterogeneous fundic gastric mass with central necrosis and fistulization into the gastric lumen. Endoscopy showed an ulceroproliferative fundic process. Gastric biopsy disclosed a spindle-cell neoplasm with strong diffuse CD117 expression; DOG1, AE1/AE3, CD45, desmin, and smooth-muscle actin were negative. The findings supported two synchronous primary tumors rather than metastatic breast cancer. The patient was reviewed by a multidisciplinary team and received systemic treatment described in the records as chemotherapy, which remained ongoing at the latest follow-up.
Abstract Gastric metastasis from breast cancer is rare and frequently misdiagnosed as primary gastric adenocarcinoma. Mixed ductal-lobular carcinoma demonstrates a unique metastatic pattern with a predilection for the gastrointestinal tract and serosal surfaces, creating significant diagnostic and therapeutic challenge...
H. Al-Otaibi, Ali Basha, Tahani AlBaqer et al.· Journal of Surgical Case Rep...· 0 citations
Background: Metaplastic breast carcinoma with mesenchymal differentiation is a rare and morphologically heterogeneous malignancy that may show a biphasic epithelial and sarcomatoid pattern historically termed “carcinosarcoma.” Its synchronous occurrence with invasive papillary carcinoma is exceptionally uncommon and ma...
Vladimir Tvrdišić, V. Vulovic, Bojan Stojanović et al.· Journal of Clinical Medicine· 0 citations
Background: The occurrence of multiple primary malignancies in a single patient is uncommon and presents significantdiagnostic challenges, particularly when metastatic lesions obscure the primary origin. Case: A 60-year-old postmenopausal woman with a history of untreated breast carcinoma presented with acute abdominal...
Patricia Diana Prasetiyo, Jennifer Jesse Limanto, A. O. Djohansjah et al.· Medicinus· 0 citations
Metaplastic breast carcinoma is a rare and aggressive subtype of invasive breast carcinoma accounting for <1% of allbreast malignancies. Among its variants, chondroid differentiation is particularly uncommon. A 36-year-old femalewith a known history of ovarian carcinoma, post total abdominal hysterectomy with bilateral...
Shivani Khillare, Bhushan M. Warpe Warpe, Shweta S. Joshi Joshi· Indian Journal of Case Repor...· 0 citations
This series illustrates that gastric and GOJ metastases from breast carcinoma are morphologically and endoscopically heterogeneous and are not confined to E-cadherin-negative ILC.
Guo Hou Loo, Y. Wong, N. F. Ab Muin et al.· Frontiers in Oncology· 0 citations
Background: In patients with metastatic breast carcinoma, newly identified visceral or pulmonary lesions may represent progression of the known malignancy or, less commonly, a distinct second primary tumor. Histopathological and immunohistochemical evaluation is therefore essential for establishing tumor lineage and gu...
Adeline R. Bucur, Alexandru Cristian Cindrea, P. Curescu et al.· Diagnostics· 0 citations
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