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Efficacy of donepezil in patients with chronic tinnitus

Elaine Miwa Watanabe L. G. Vasconcelos Maria F. Bonadia-Moraes F. Husain N. J. C. Duarte J. Oiticica
Jan 2026 · Clinics · Vol 81, pp. 101135 · 1 citation · 32 references
Medicine

TL;DR

Donepezil may offer a pharmacological option for tinnitus management and may offer a pharmacological option for tinnitus management among amplification users.

Abstract

Highlights • Donepezil has not been evaluated in patients with tinnitus.• Donepezil may offer a pharmacological option for tinnitus management.• THI responder analysis suggested a trend favoring donepezil.• Treatment benefits appeared greater among amplification users.• Complete tinnitus remission occurred only in the donepezil group.

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