A piece-wise linear recurrent neural network identifies generalizable dynamics from neural activity during decision-making in rodents

Abstract

Alterations in impulsivity characterize several neuropsychiatric disorders, however the neural processes that underlie an impulsive choice have not been identified. A recent body of literature suggests that there may be generalizable aspects of neural representations across animals. Whether this is also true for dynamic rather than just static (like geometrical) properties of neural representations, and specifically in the context of impulsive behaviors, is less clear. Therefore, the goal of this study is to characterize generalizable features of latent dynamics that disambiguate an impulsive from non-impulsive choice across many different data sets and animals. A deep learning-based latent factor model was constructed from neural recordings that were acquired in rat anterior cingulate cortex while performing a delay discounting task, which is commonly used to assess impulsivity. Prior work shows this brain region is critical for the performance of this task. We leveraged piecewise linear recurrent neural networks (PLRNNs) to perform a nonlinear latent factor analysis across animals and experimental sessions. Our PLRNN explained a substantially larger percent of variance in fewer dimensions than linear approaches. We cross-validated performance of the model on test data and following the disruption of recurrent connectivity or auto-regressive latent dynamics. These tests confirmed that our fitting procedure consistently embedded generalizable neuronal dynamics within the PLRNN. Further, we found that the latent dynamics exhibited strong rotational features and progressed faster for impulsive choices. In summary, our model captures properties of the latent dynamics that are consistent across multiple data sets and disambiguate impulsive choices.