Skip to content

The strength of clinical evidence is recoverable from language model representations but not from their stated grades

Jun 2026 · arXiv.org · Vol abs/2606.29034 · 1 citation · 57 references
Computer Science

TL;DR

Clinical LLMs carry an ordered evidence-strength signal they do not express, so their stated grades fail to convey a claim's support even when it is recoverable from their representations and text.

Abstract

Large language models (LLMs) increasingly summarize clinical evidence, where a claim's weight depends on how strongly it is supported. Yet these models convey confidence poorly, and properties they never state, such as truth, are often readable from their activations. Whether a clinical model registers evidence strength, distinct from truth, and states it when asked is untested, and any such signal could be lexical. We compiled 45,134 clinical claims from six public sources, harmonized 20,611 into a four-level evidence grade under three independent frameworks, and tested 22 local, open-weight LLMs from several developers (0.6-70 billion parameters; general, medical, and reasoning), with lexical, truth, and cross-framework controls. A linear estimator recovered the grade in every model (median AUROC 71.8), yet decodability did not rise with scale and was weakest in reasoning models. The grade the models stated fell to chance, 25-27 percentage points below the estimator. The recoverable signal was largely lexical and did not transfer across topics or frameworks, yet it was distinct from factual truth and still flagged weakly supported claims (AUROC 69.2). Clinical LLMs thus carry an ordered evidence-strength signal they do not express, so their stated grades fail to convey a claim's support even when it is recoverable from their representations and text.

View source

Similar papers

Review Open access Aug 2026

Explainability of decoder-only clinical large language models: A scoping review

Findings show that clinical LLM explainability has shifted toward fluent generative rationales, but evidence that such explanations reflect model reasoning remains limited, and three regulatory priorities are highlighted: prioritizing explanations that enable independent verification or logic auditing over plausibility...

Nishant Mishra, A. Abu-Hanna, Iacer Calixto · 1 citation
Jun 2026

CLExEval: A Human-in-the-Loop Framework for Qualitative Evaluation of LLM Clinical Reasoning

Large Language Models (LLMs) achieve strong results on many medical benchmarks, but their clinical reasoning remains difficult to evaluate reliably. A central risk is an evaluation illusion: fluent and well-structured explanations can appear clinically convincing even when the final diagnosis is incorrect. We introduce...

Abin Roy, Afthab Salam Kanniyan, Jawadh Abdul Kabeer et al. · 0 citations
Preprint Aug 2026

Generated Context versus Governed State: Functional Conditions for Accountable Longitudinal Clinical Reasoning

This paper argues that longitudinal clinical reasoning is a state-estimation problem under partial observability, and that the axis on which clinical AI succeeds or fails is not the fluency of the model reading the record but the governance of the patient state it reasons over.

Augusto Bernardo Pissarra, Victor Farias DE Souza · 0 citations
Jul 2026

Information-seeking failures of large language models in agentic clinical reasoning

Large language models achieve high scores on medical knowledge assessments, yet clinical reasoning requires actively deciding what to investigate under uncertainty. We developed an agentic evaluation framework in hematologic oncology in which models must proactively request clinical data across three sequential rounds...

K. Braitsch, L. Schmalbrock, Theresa Weltermann et al. · 1 citation
Conference Jul 2026

Multi-Agent Medical Debate System for Clinical Reasoning

Clinical deployment of large language models (LLMs) for medical question answering faces three primary challenges: (1) models frequently produce unsupported or hallucinated claims because their parametric knowledge is not verified against biomedical evidence; (2) single-pass inference prevents iterative self-correction...

Shreyas Bhoyar, Adil Ansari, N. Saxena · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.