The findings suggest that rs7527192 may be associated with cervical cancer susceptibility in this cohort, and rs1136410 influences the PARP1 expression; however, independent validation in larger, multiethnic, and functionally characterized cohorts with HPV adjustment is required.
Exonuclease 1 (
EXO1
) is a key nuclease in the DNA mismatch repair (MMR) pathway and is involved in correcting replication errors while maintaining genomic stability. The K589E (rs1047840) single nucleotide polymorphism (SNP) of
EXO1
has been associated with cancer susceptibility in different populations....
Mahmudul Kabir, M. Rahman, Sm Faysal Bellah et al.· Breast Cancer: Basic and Cli...· 0 citations
Background Cytochrome P450 3A5 (CYP3A5) is a key xenobiotic‐metabolizing enzyme that also participates in the biotransformation of endogenous substrates. Functional genetic variation within CYP3A5 can alter enzyme activity and may consequently modify individual susceptibility to malignancy. The contribution of CYP3A5 g...
It is demonstrated that mainstreamed germline and somatic BRCA1/2 testing is feasible in Ireland and reports the prevalence of BRCA CAVs in a cohort of patients with OC, which is consistent with UK real-world data.
C. McNevin, Kate Murphy, P. Murchan et al.· European Journal of Human Ge...· 0 citations
The CYP1A1 rs1048943 polymorphism was not associated with laryngeal cancer susceptibility in this Sudanese cohort, and larger studies are needed to clarify the genetic basis of laryngeal carcinogenesis.
Marwa Abdalwahab, M. Ellaithi· F1000Research· 0 citations
In conclusion, SIRT1 rs3758391 may serve as a potential genetic susceptibility marker for breast cancer in Bangladeshi women, whereas the association of rs12778366 appears less robust after age adjustment.
Fariya Aboni, M. N. K. Manik, Zimam Mahmud et al.· Journal of Genetic Engineeri...· 0 citations
BACKGROUND
Psoriasis is a chronic, immune-mediated skin disease characterized by keratinocyte hyperproliferation and persistent inflammation. Recent studies suggest that long non-coding RNAs (lncRNAs), such as HOX transcript antisense RNA (HOTAIR), may play critical roles in regulating inflammatory pathways involved in...
Egemen Akgun, F. M. Içduygu, B. Akşan et al.· Advances in Clinical and Exp...· 0 citations
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