Beyond Explanation: Debugging Medical Imaging Models via Concept Intervention
Samrajya ThapaDaniel J. QuestTimothy L. KlineCarrie L. LangstraatEmanuel C. TrabucoWei Le
Oct 2026
Machine LearningComputer Vision
Abstract
Medical imaging models often operate as black boxes, limiting interpretability and systematic debugging. We introduce an easy-to-use, plug-and-play framework for concept-based interpretation and model refinement. By aligning a single-modality encoder to BioMedCLIP, we construct a Concept Bottleneck Model (CBM) that enables concept-level interventions. These interventions allow us to isolate causal versus spuriously correlated concepts, validate insights with domain experts, and generate counterfactual samples for targeted fine-tuning. We evaluate our framework on a Mayo Clinic ultrasound dataset and the CheXpert 5x200 chest X-ray dataset. Results demonstrate that concept intervention enables reliable model diagnosis while maintaining, and occasionally improving predictive performance via guided fine-tuning. Our findings highlight the practical value of this framework for controlled, interpretable refinement of clinical deep learning models.
This publication proposes a definition and a classification of agile software development approaches and analyses ten software development methods that can be characterized as being "agile" against the defined criterion.
P. Abrahamsson, O. Salo, Jussi Ronkainen et al.· arXiv.org· 727 citations· ⚡54
The study shows that agile practices improve both informal and formal communication, but indicates that, in larger development situations involving multiple external stakeholders, a mismatch of adequate communication mechanisms can sometimes even hinder the communication.
M. Pikkarainen, Jukka Haikara, O. Salo et al.· Empirical Software Engineeri...· 401 citations· ⚡48
The results indicate that software engineering work practices are chosen opportunistically, adapted and configured to provide value under the constrains imposed by the startup context.
Nicolò Paternoster, Carmine Giardino, M. Unterkalmsteiner et al.· Information and Software Tec...· 394 citations· ⚡54
The possibility of inferring high-dimensional data inference in a model that consists of a prior and an auxiliary differentiable constraint given some additional information is considered, thereby allowing a range of potential applications in adapting models to new domains and tasks.
Alexandros Graikos, Esmeralda S. Whitammer, N. Jojic et al.· Neural Information Processin...· 316 citations· ⚡15
It is proved that any global minimizer of the trajectory balance objective can define a policy that samples exactly from the target distribution, and empirically demonstrate the benefits of the trajectories balance objective for GFlowNet convergence, diversity of generated samples, and robustness to long action sequenc...
Esmeralda S. Whitammer, Moksh Jain, Emmanuel Bengio et al.· Neural Information Processin...· 302 citations· ⚡60
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
Microsoft Research Blog· microsoft.comAug 11, 2026
Radiology AI is evolving beyond report generation. CARE-X explores a unified approach that combines flexible reasoning, calibrated predictions, and measurement-based tools for chest X-ray interpretation. The post Introducing CARE-X: Towards Clinically Useful Radiology VLMs with Auxiliary Supervision, Reward-Aligned Learning, and Tool-Augmented Measurement appeared first on Microsoft Research.
Students in MIT’s Concourse program delve deeply into the human condition, debate challenging questions, and learn to develop judgment about issues that can’t be quantified.
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
