TL;DR
The thyroid malignancy calculator showed excellent discrimination but imperfect calibration in this selected surgical cohort, and Prospective validation and clinical-impact assessment in unselected populations are required before it is used to alter fine-needle aspiration decisions.
BACKGROUND Bethesda Category III thyroid nodules (AUS/FLUS) pose a diagnostic challenge due to their malignancy rate of 15-30%. This study aimed to develop and validate a preoperative nomogram combining ultrasonographic features and BRAF V600E mutation status to enhance individualized risk assessment. METHODS We anal...
Objective: To evaluate the association between preoperative thyroid-stimulating hormone (TSH) levels and postoperative histopathological malignancy in patients undergoing thyroidectomy for thyroid nodules, and to compare the discriminative performance of TSH with that of TI-RADS.Material and Methods: A total of 366 pat...
Clinical warning symptoms combined with ultrasound findings improved preoperative risk stratification and may support earlier diagnosis and appropriate surgical management in resource-limited settings.
The 2025 American Thyroid Association (ATA) guidelines maintained the low- and high-risk categories and subdivided the intermediate-risk category of differentiated thyroid cancer (DTC) into low-intermediate and intermediate-high tiers. To determine whether observed rates of structural disease match the ris...
Objective To analyze the correlation between inflammation, nutrition and metabolic indicators and the risk of papillary thyroid carcinoma (PTC), and to construct and validate a nomogram for predicting PTC risk among patients with thyroid nodules undergoing surgery, to assist clinicians in making more individualized cli...
Background: The 2025 American Thyroid Association (ATA) guidelines introduced significant modifications to the initial risk stratification system for differentiated thyroid cancer (DTC). However, the real-world prognostic performance and stage migration effects of these updates compared with the 2015 system remain unev...
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