TL;DR
expression and inhibition of miR-214 indicated that miR-214 acts as an oncogenic miRNA and may contribute to the progression, and metastasis of OS, suggesting that miR-214 may be a potential novel diagnostic and therapeutic target of OS.
MicroRNA-2110 has been implicated in cancer, but its expression and function in gastric cancer (GC) remain understudied. This study aims to explore the role of miR-2110 in GC and its regulation of IGF1R. RT-qPCR was used to measure miR-2110, IGF1R expression in 138 paired GC and adjacent normal tissues. Ex...
It is revealed that miR-234-3p inhibits OC progression by directly targeting WNK2 and thereby attenuating the Ras/MEK/ERK/ERG pathway.
miRNAs are small molecules which influence cellular function by regulating the expression of mRNA. They control various stages of the cell’s existence, including differentiation, proliferation and finally death. In cancer cells, miRNAs can become dysregulated, enabling the cell to escape growth suppression and resist...
Evidence is provided that miR-135 acted as a tumor suppressor in Bc, which may represent a novel therapeutic strategy for the diagnosis and prognosis of Bc.
The findings suggest that the effects of MIR100HG on oncogenic signaling are highly dependent on the cellular oxygenation context and that hypoxia reshapes the downstream signaling consequences of MIR100HG expression in HCC cells.
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