[Anwulignan inhibits malignant phenotypes of gastric cancer cells by antagonizing activation of the JAK1/STAT3 signaling pathway].

Molecular mechanism by which dichotomitin inhibits growth and metastasis of gastric cancer MKN-45 cells via the EGFR/ROS signaling pathway.

Dichotomitin inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed migration in GC cells by modulating EGFR-related ROS-dependent signaling pathways.

Propranolol attenuates the malignant biological behaviors of renal cancer cells partly through modulation of the IL-6/PI3K/AKT signaling axis

Objective To investigate the effects of propranolol on the malignant biological behaviours of renal cancer cells and explore the potential involvement of the IL-6/PI3K/AKT signalling axis. Methods 786-O and Caki-2 ccRCC cells were treated with gradient propranolol, followed by CCK-8, wound-healing, Transwell and flow c...

Sophocarpine Inhibits Proliferation and Triggers Apoptosis in Breast Cancer Cells by Modulating the miR-21/PTEN/AKT and ERK1/2 Signaling Networks

Findings identify SC as a potential structural scaffold exhibiting preliminary anti-tumor activity against breast cancer cells, at least in part, through modulating miR-21 and inhibition of the AKT/mTOR/ERK1/2 survival network.

Effect of EZH2 regulation of the JAK2/STAT3 signaling pathway on proliferation and apoptosis in non-small cell lung cancer cells

It is demonstrated that EZH2 promotes NSCLC progression through activation of the JAK2/STAT3 signaling pathway, identifying the EZH2-JAK2/STAT3 axis as a potential therapeutic vulnerability in this malignancy.

GLIS3 promotes the malignant biological behavior of gastric cancer cells by transcriptionally regulating PNPO to influence autophagy

Up-Regulation of FBXO17 Promotes Ferroptosis and Suppresses the Stemness of Prostate Cancer Cells Through Wnt/β-Catenin Pathway.

By hindering the Wnt/β-catenin pathway, overexpression of FBXO17 promotes ferroptosis and subsequently inhibits the malignant phenotype and stemness properties of PCa cells.