TL;DR
An in-depth, subcellular perspective on how nuclear, cytoplasmic, and mitochondrial sirtuins synergistically protect against cardiovascular remodeling, atherosclerosis, and heart failure is provided.
Sirtuins (SIRT1–SIRT7) are evolutionarily conserved NAD+-dependent deacylases that function as metabolic sensors, coupling cellular metabolic state to epigenetic, transcriptional and post-translational regulatory programs across distinct subcellular compartments. Despite two decades of research, isoform- and disease-sp...
Protein lysine acetylation is a widespread post-translational modification that regulates metabolic enzyme activity and cellular function. Sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases that act as key metabolic sensors coupling cellular energy status to the regulation...
INTRODUCTION Sirtuins (SIRT1-7) are NAD+-dependent lysine deacylase and mono-ADP ribosyl transferase enzymes that integrate metabolic status with epigenetic regulation, genome maintenance, mitochondrial homeostasis, and adaptive stress responses. Their dysregulation is implicated in cancer, neurodegeneration, cardiomet...
SIRT2, an NAD+-dependent deacetylase, is increasingly recognized as an important regulator of cellular metabolism and aging. By deacetylating diverse substrates, SIRT2 influences glucose metabolism, lipid metabolism, mitochondrial function, cytoskeletal dynamics, oxidative stress, and inflammatory responses, thereby co...
SIRT6 is a NAD+-dependent sirtuin that plays central roles in chromatin regulation, DNA repair, telomere maintenance, metabolic homeostasis, and inflammatory control. Although SIRT6 have long been implicated in aging because of its association with several hallmarks of aging, the available evidence remains largely cont...
This synthesis provides a framework for understanding how SUMOylation links metabolic stress to tissue-specific aging trajectories and therapeutic potential and evaluates emerging translational approaches that highlight both the opportunities and challenges of targeting SUMO-regulated stress responses in aging.
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