Dynamic single-cell transcriptomic analysis of peripheral blood mononuclear cells identifies novel biomarkers for autoimmune encephalitis.

Anti-CD20 B cell depletion is associated with elevated mucosal-originating circulating regulatory IgA B cells in multiple sclerosis.

It is found that anti-CD20 B cell depletion was associated with increased frequencies of regulatory mucosal-derived IgA-producing B cells in the periphery and CSF, together with increased B cell receptor clonal overlap between mucosal and systemic compartments, indicating enhanced trafficking of IgA B cells from gut mu...

Integrated peripheral immune profiling reveals B-cell dysregulation and CD8 effector signatures in chronic inflammatory demyelinating polyneuropathy

Integrated peripheral immune profiling identified candidate CIDP-associated immune signatures including dysregulated B-cell activation despite numerical reduction and a prominent cytotoxic CD8 T-cell program within a type I interferon– and inflammasome-skewed inflammatory milieu.

Single-cell analysis suggests coordinated immune-cell redistribution between blood and cerebrospinal fluid in early multiple sclerosis

Despite immune-cell infiltration being a hallmark of multiple sclerosis (MS), the interplay between the periphery and central nervous system immune responses is still incompletely characterized. We performed single-cell transcriptomic and V(D)J sequencing of paired blood and cerebrospinal fluid (CSF) immune cells from...

Distinct peripheral B-cell immunophenotypes define clinical heterogeneity in childhood-onset systemic lupus erythematosus

B-cell dysregulation is central to the pathogenesis of childhood-onset systemic lupus erythematosus (cSLE), yet the B-cell immunophenotypes across disease states remain incompletely defined. This study aimed to investigate the mechanistic basis and clinical relevance of B-cell–mediated immune dysregulation in cSLE. Per...

Hepatic CD8+TOX+ T-cells are a hallmark of autoimmune hepatitis

Characterizing Memory T Cells Associated with Systemic Lupus Erythematosus Pathogenesis

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease associated with a severe morbidity and mortality. Around 70% of SLE patients follow a relapse-remitting pattern of disease characterized by flares of disease activity, followed by prolonged periods of disease quiescence. Memory CD4+ T cell subsets h...