Jul 2026· Cranio· pp.
1-12
· 0 citations· 39 references
Medicine
TL;DR
The relationships between PFAS exposure and OSA risk are characterized by compound-specific, concentration-dependent, and sex-dimorphic patterns.
Abstract
Objective
Epidemiological and toxicological studies have associated perfluoroalkyl and polyfluoroalkyl substances (PFAS) with adverse effects on multiple organ systems. However, the potential link between PFAS exposure and obstructive sleep apnea (OSA) remains limited.
Methods
2,960 participants were selected from two cycles of National Health and Nutrition Examination Survey. OSA was evaluated by the multivariable apnea prediction index, and serum concentrations of nine PFAS were detected. Weighted logistic regression, RCS, and WQS regression were used to assess individual, nonlinear, and mixture associations.
Results
PFDeA and PFUA showed significant inverse dose-response relationships, with quartile-based analyses showing protective effects for PFDeA, PFHxS, Me-PFOSA-AcOH, PFUA, and n-PFOS. RCS analyses revealed L-shaped nonlinear relationships for PFDeA and PFUA. Sex-stratified analyses identified a female-specific inverse association for Sm-PFOS (P for interaction = 0.025). WQS regression indicated significant protective mixture effects (OR = 0.69, P = 0.007), predominantly driven by PFUA, followed by n-PFOA and PFHxS.
Conclusion
The relationships between PFAS exposure and OSA risk are characterized by compound-specific, concentration-dependent, and sex-dimorphic patterns.
The inverse link between PFAS co-exposure and asthma incidence persisted across multi-pollutant models, weighted quantile sum regression, and Bayesian kernel machine regression models, with PFOS emerging as the primary negative influencer.
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants linked to various diseases, yet their association with arterial stiffness remains unclear. Using data from 5209 U.S. adults in the National Health and Nutrition Examination Survey (2011-2018), the association between PFAS exposure and estimated pulse wave velocity (ePWV) was investigated via multiple statistical approaches. In single-exposure models, perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS), but not perfluorononanoic acid (PFNA), were significantly associated with elevated ePWV. PFOS exhibited a nonlinear dose-response relationship. However, mixture analyses (Weighted Quantile Sum regression and Quantile G-computation models) detected no significant overall mixture effect. Exploratory component rankings and an Extreme Gradient Boosting model interpreted with SHapley Additive exPlanations consistently identified PFOS as the predominant driver. Exploratory mediation analyses suggested that oxidative stress (serum uric acid and gamma-glutamyl transferase [GGT]) and mineral homeostasis (serum calcium) may serve as potential mediating pathways, although the nonspecific signals for uric acid, and inconsistent GGT findings across PFAS congeners warrant cautious interpretation. Subgroup analyses indicated greater susceptibility in females and partnered individuals. Overall, these findings provide hypothesis-generating evidence for potential pathways and offer exploratory insights for prevention, while also highlighting the need for future studies employing more direct measures.
De-Xiang Xia, Rui Li, Chang Shu et al.· Ecotoxicology and Environmen...· 0 citations
It is suggested that PFAS may be linked to inflammation and impaired fibrinolysis in midlife women, and none of these associations remained statistically significant after false discovery rate correction.
Yun-Dan Zhang, Wenzhi Zhang, Carrie A. Karvonen-Gutierrez et al.· JACC: Advances· 0 citations
Mixture exposure showed a significant positive association with chronic obstructive pulmonary disease risk, and these substances disrupt pulmonary homeostasis through concurrent molecular activation and lipid-metabolic disturbance, evidenced by triglyceride-glucose index mediation.
Yansong Hu, Huanyu Cui, Yakun Wang et al.· BMC Pulmonary Medicine· 0 citations
It is suggested that higher plasma PFAS concentrations, particularly HFPO-DA, may be associated with more advanced TNM stage in colorectal cancer and warrant confirmation in larger prospective studies.
Ning Kang, Yang Zhao, Zhi Huang et al.· Frontiers in Toxicology· 1 citation
Limiting to directly measured exposures, incorporating the full NHANES design in the primary regression, and triangulating across complementary mixture frameworks provide a more rigorous platform than prior single-pollutant or design-naive approaches.
Rifa Tasnia, E. Obeng-Gyasi· Journal of Xenobiotics· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
